Diversity, stability and resilience of the human gut microbiota

被引：3918

作者：

Lozupone, Catherine A. ^{[1
]}

Stombaugh, Jesse I. ^{[1
]}

Gordon, Jeffrey I. ^{[2
]}

Jansson, Janet K. ^{[3
,4
]}

Knight, Rob ^{[1
,5
,6
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[2] Washington Univ, Ctr Genome Sci & Syst Biol, St Louis, MO USA

[3] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA

[4] Lawrence Berkeley Natl Lab, Joint Genome Inst, Walnut Creek, CA USA

[5] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

[6] Univ Colorado, Biofrontiers Inst, Boulder, CO 80309 USA

来源：

NATURE | 2012年 / 489卷 / 7415期

关键词：

INFLAMMATORY-BOWEL-DISEASE; INTESTINAL MICROBIOTA; CLOSTRIDIUM-DIFFICILE; CROHNS-DISEASE; ANTIBIOTIC-TREATMENT; MOLECULAR ANALYSIS; FECAL MICROBIOTA; BODY HABITATS; SEQUENCE DATA; HUMAN COLON;

D O I：

10.1038/nature11550

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host interactions. Understanding the factors that underlie changes in the composition and function of the gut microbiota will aid in the design of therapies that target it. This goal is formidable. The gut microbiota is immensely diverse, varies between individuals and can fluctuate over time - especially during disease and early development. Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.

引用

页码：220 / 230

页数：11

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