Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway

被引：146

作者：

Fleming, HE ^{[1
]}

Paige, CJ

机构：

[1] Univ Toronto, Ontario Canc Inst, Princess Margaret Hosp, Univ Hlth Network,Dept Immunol, Toronto, ON, Canada

[2] Univ Toronto, Ontario Canc Inst, Princess Margaret Hosp, Univ Hlth Network,Dept Med Biophys, Toronto, ON, Canada

来源：

IMMUNITY | 2001年 / 15卷 / 04期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/S1074-7613(01)00216-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B lymphocyte development is regulated at multiple checkpoints, mediated by signals originating both inside and outside the cell. Two signaling pathways known to be essential in this process are interleukin-7 (IL-7) and the pre-B cell receptor (pBCR). We have shown previously that these signaling pathways intersect functionally. Specifically, response to low concentrations of IL-7 requires pBCR expression. In this report, we identify the ERK/MAP kinase pathway as a key regulatory component of this response. We propose a molecular mechanism for the selective expansion of pBCR(+) precursors and for the culling of inappropriately rearranged pro-B cells.

引用

页码：521 / 531

页数：11

共 63 条

[1] PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO [J].