Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: a case series from 2010 to 2014

被引：24
作者：
Dona, Maria Gabriella [1 ]
Spriano, Giuseppe [2 ]
Pichi, Barbara [2 ]
Rollo, Francesca [3 ]
Laquintana, Valentina [3 ]
Covello, Renato [3 ]
Pellini, Raul [2 ]
Giuliani, Massimo [1 ]
Pescarmona, Edoardo [3 ]
Benevolo, Maria [3 ]
机构：
[1] IRCCS, San Gallicano Dermatol Inst, STI Unit, I-00144 Rome, Italy
[2] IRCCS, Regina Elena Natl Canc Inst, Otolaryngol Head Neck Surg Dept, I-00144 Rome, Italy
[3] IRCCS, Regina Elena Natl Canc Inst, Dept Pathol, I-00144 Rome, Italy
来源：
FUTURE MICROBIOLOGY | 2015年 / 10卷 / 08期
关键词：
head and neck neoplasms; human papillomavirus; oropharyngeal neoplasms; p16INK4; protein; prevalence; ORAL HUMAN-PAPILLOMAVIRUS; HPV-DNA; NECK-CANCER; HEAD; PREVALENCE; IMMUNOHISTOCHEMISTRY; VALIDATION; PROGNOSIS; TONSILLAR; WORLDWIDE;
D O I：
10.2217/FMB.15.55
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression and HPV-attributable fraction in recent consecutive OPSCCs. Materials & methods: 140 OPSCCs were analyzed for HPV-DNA using the INNO-LiPA assay and p16 overexpression using CINtec (R) Histology kit. Results: HPV-DNA prevalence was 40.7%, and was significantly higher in basaloid and nonkeratinizing SCCs, but similar in tonsillar and base of tongue SCCs. Moreover, 98.0% of the HPV-positive OPSCCs overexpressed p16, compared with 12.3% of the HPV-negative cases (p < 0.0001). Based on HPV-DNA and p16 double positivity, 39.8% of the cases were HPV related. Conclusion: The high estimate of the HPV-attributable fraction suggests that a substantial proportion of OPSCC patients may be managed less intensively.
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收藏
页码：1283 / 1291
页数：9
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