Association of Dietary Quercetin With Reduced Risk of Proximal Colon Cancer

被引:42
作者
Djuric, Zora [1 ,2 ]
Severson, Richard K. [3 ]
Kato, Ikuko [4 ,5 ]
机构
[1] Univ Michigan, Dept Family Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
[3] Wayne State Univ, Sch Med, Dept Family Med & Publ Hlth Sci, Detroit, MI USA
[4] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI USA
[5] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2012年 / 64卷 / 03期
关键词
BETA-CAROTENE SUPPLEMENTATION; ABERRANT CRYPT FOCI; COLORECTAL-CANCER; FLAVONOID INTAKE; MICROSATELLITE INSTABILITY; POOLED ANALYSIS; ANTIOXIDANT ACTIVITIES; DISTAL COLON; POPULATION; PATTERN;
D O I
10.1080/01635581.2012.658950
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Quercetin is a flavonol that appears to be protective against several cancers, but its possible role in prevention of colorectal cancer is not yet well studied. We evaluated dietary intakes of quercetin and risk of colorectal cancer in a large case-control study conducted in metropolitan Detroit, Michigan (N = 2664). The protective effects of quercetin intake, as assessed by a food frequency questionnaire, were confined to risk of proximal colon cancer. Stratified analyses showed that the protective effects of quercetin on risk of proximal colon cancer were significant only when fruit intake or the Healthy Eating Index score was high, or when tea intake was low, with Odds ratios (OR) for the highest vs. the lowest quartile of 0.49, 0.44, and 0.51, respectively. Increased quercetin intake had no protective effects when tea intake was high. Interestingly, increased intake of quercetin was associated with increased risk of distal colon cancer when total fruit intake was low (OR for the highest vs. the lowest quartile = 1.99). These results suggest that quercetin can have disparate effects on colon cancer risk depending on whether dietary intakes of fruit or tea are high, and that quercetin had protective effects only on proximal, not distal, colon cancer.
引用
收藏
页码:351 / 360
页数:10
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