Intermittent supplementation with rapamycin as a dietary restriction mimetic

被引：30

作者：

Longo, Valter D. ^{[1
]}

Fontana, Luigi ^{[2
,3
]}

机构：

[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

[3] Ist Super Sanita, Div Nutr & Aging, I-00161 Rome, Italy

来源：

AGING-US | 2011年 / 3卷 / 11期

关键词：

EXTENDS LIFE-SPAN; TOR; KINASE;

D O I：

10.18632/aging.100401

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1039 / 1040

页数：2

共 17 条

[1]

Anisimov VN, 2011, CELL CYCLE IN PRESS, V10

[2] Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation [J].

Campistol, Josep M. ;

Cockwell, Paul ;

Diekmann, Fritz ;

Donati, Donato ;

Guirado, Luis ;

Herlenius, Gustaf ;

Mousa, Dujanah ;

Pratschke, Johann ;

San Millan, Juan Carlos Ruiz .

TRANSPLANT INTERNATIONAL, 2009, 22 (07) :681-687

[3] Regulation of longevity and stress resistance by Sch9 in yeast [J].

Fabrizio, P ;

Pozza, F ;

Pletcher, SD ;

Gendron, CM ;

Longo, VD .

SCIENCE, 2001, 292 (5515) :288-290

[4]

Fontana L, 2010, HDB BIOL AGING

[5] Extending Healthy Life Span-From Yeast to Humans [J].

Fontana, Luigi ;

Partridge, Linda ;

Longo, Valter D. .

SCIENCE, 2010, 328 (5976) :321-326

[6] The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation [J].

Geissler, Edward K. ;

Schlitt, Hans J. .

KIDNEY INTERNATIONAL, 2010, 78 (11) :1075-1079

[7] Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans [J].

Guevara-Aguirre, Jaime ;

Balasubramanian, Priya ;

Guevara-Aguirre, Marco ;

Wei, Min ;

Madia, Federica ;

Cheng, Chia-Wei ;

Hwang, David ;

Martin-Montalvo, Alejandro ;

Saavedra, Jannette ;

Ingles, Sue ;

de Cabo, Rafael ;

Cohen, Pinchas ;

Longo, Valter D. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (70)

[8] Rapamycin fed late in life extends lifespan in genetically heterogeneous mice [J].

Harrison, David E. ;

Strong, Randy ;

Sharp, Zelton Dave ;

Nelson, James F. ;

Astle, Clinton M. ;

Flurkey, Kevin ;

Nadon, Nancy L. ;

Wilkinson, J. Erby ;

Frenkel, Krystyna ;

Carter, Christy S. ;

Pahor, Marco ;

Javors, Martin A. ;

Fernandez, Elizabeth ;

Miller, Richard A. .

NATURE, 2009, 460 (7253) :392-U108

[9] Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway [J].

Kapahi, P ;

Zid, BM ;

Harper, T ;

Koslover, D ;

Sapin, V ;

Benzer, S .

CURRENT BIOLOGY, 2004, 14 (10) :885-890

[10] Calorie restriction and cancer prevention: metabolic and molecular mechanisms [J].

Longo, Valter D. ;

Fontana, Luigi .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2010, 31 (02) :89-98

← 1 2 →