IL-10 gene polymorphism at-1082 A/G is associated with severe rhinovirus bronchiolitis in infants

被引：62

作者：

Helminen, Merja ^{[1
,2
]}

Nuolivirta, Kirsi ^{[3
]}

Virta, Miia ^{[4
]}

Halkosalo, Anne ^{[5
]}

Korppi, Matti ^{[1
,2
]}

Vesikari, Timo ^{[5
]}

Hurme, Mikko ^{[4
]}

机构：

[1] Tampere Univ Hosp, Paediat Res Ctr, Tampere 33521, Finland

[2] Tampere Univ, Paediat Res Ctr, Tampere, Finland

[3] Tampere Univ, Tampere & Seinajoki Cent Hosp, Paediat Res Ctr, Seinajoki, Finland

[4] Univ Tampere, Sch Med, Tampere Univ Hosp, Dept Microbiol & Immunol,Lab Ctr, FIN-33101 Tampere, Finland

[5] Univ Tampere, Sch Med, Vaccine Res Ctr, Tampere, Finland

来源：

PEDIATRIC PULMONOLOGY | 2008年 / 43卷 / 04期

关键词：

wheezing; cytokine polymorphism; child;

D O I：

10.1002/ppul.20793

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We analyzed polymorphisms of IL-10-1082G/A, IL-18-137G/C, TLR4+896A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL-10-1082 allele G non-carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). Infants with RSV bronchiolitis did not differ from controls. This finding suggests a different pathogenic mechanism for RSV bronchiolitis as compared with wheezing associated with other viral infections, for example, rhinovirus in infants under 6 months of age.

引用

页码：391 / 395

页数：5

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