DaTQUANT: The Future of Diagnosing Parkinson Disease

被引:36
作者
Brogley, Jacquelyn E. [1 ]
机构
[1] Gateway Community Coll, Nucl Med Technol Program, Phoenix, AZ USA
关键词
Parkinson's disease; I-123; Ioflupane; dopamine transporter; DaTQUANT (R); DISORDERS;
D O I
10.2967/jnmt.118.222349
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Idiopathic Parkinson disease (PD) is a progressive neurologic condition that affects the dopamine transporters in the substantia nigra of the brain. Currently, more than 10 million people are living with this disease worldwide, with thousands of newly diagnosed and undiagnosed cases added every year. The disease is difficult to differentiate from other similar disorders, as symptoms widely vary and can mimic other conditions. Classic PD symptoms may look similar to essential tremor and other parkinsonian syndromes. The I-123-ioflupane dopamine transporter (DaT) protocol differentiates PD from essential tremor through in vivo testing with SPECT imaging. The DaT protocol commonly relies on a semiquantitative analysis and visual interpretations of the images, which may produce inaccurate results due to human error. DaTQUANT software (GE Healthcare) was created in 2013 as an adjunct processing tool with advanced quantitative uptake methods and a designated normals database for a more accurate assessment of a patient's case. DaTQUANT has proven to be a vital protocol component for an accurate differentiation of PD from essential tremor. Current use of the software has been rather limited, so a greater push for education and implementation will be key for its success.
引用
收藏
页码:21 / 26
页数:6
相关论文
共 11 条
  • [1] [Anonymous], MADAME CURIE BIOSCIE
  • [2] [Anonymous], PARK DIS MED
  • [3] [Anonymous], DATQUANT
  • [4] Dopamine transporter imaging as a diagnostic tool for parkinsonism and related disorders in clinical practice
    Ba, Fang
    Martin, W. R. Wayne
    [J]. PARKINSONISM & RELATED DISORDERS, 2015, 21 (02) : 87 - 94
  • [5] Diagnostic Performance of the Visual Reading of 123I-Ioflupane SPECT Images With or Without Quantification in Patients With Movement Disorders or Dementia
    Booij, Jan
    Dubroff, Jacob
    Pryma, Daniel
    Yu, Jian
    Agarwal, Rajan
    Lakhani, Paras
    Kuo, Phillip H.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (11) : 1821 - 1826
  • [6] The Semicolon Sign: Dopamine Transporter Imaging Artifact from Head Tilt
    Covington, Matthew F.
    McMillan, Natalie A.
    Avery, Ryan J.
    Kuo, Phillip H.
    [J]. JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY, 2013, 41 (02) : 105 - 107
  • [7] SNM Practice Guideline for Dopamine Transporter Imaging with 123I-Ioflupane SPECT 1.0
    Djang, David S. W.
    Janssen, Marcel J. R.
    Bohnen, Nicolaas
    Booij, Jan
    Henderson, Theodore A.
    Herholz, Karl
    Minoshima, Satoshi
    Rowe, Christopher C.
    Sabri, Osama
    Seibyl, John
    Van Berckel, Bart N. M.
    Wanner, Michele
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2012, 53 (01) : 154 - 163
  • [8] Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale Presentation and Clinimetric Testing Results
    Goetz, Christopher G.
    Tilley, Barbara C.
    Shaftman, Stephanie R.
    Stebbins, Glenn T.
    Fahn, Stanley
    Martinez-Martin, Pablo
    Poewe, Werner
    Sampaio, Cristina
    Stern, Matthew B.
    Dodel, Richard
    Dubois, Bruno
    Holloway, Robert
    Jankovic, Joseph
    Kulisevsky, Jaime
    Lang, Anthony E.
    Lees, Andrew
    Leurgans, Sue
    LeWitt, Peter A.
    Nyenhuis, David
    Olanow, C. Warren
    Rascol, Olivier
    Schrag, Anette
    Teresi, Jeanne A.
    van Hilten, Jacobus J.
    LaPelle, Nancy
    [J]. MOVEMENT DISORDERS, 2008, 23 (15) : 2129 - 2170
  • [9] Mandal Ananya., News Medical
  • [10] Mayo Clinic, Parkinson's disease