Preparation and Influencing Factors of Sirolimus Liposome by Supercritical Fluid

被引：24

作者：

Zhang, Wei ^{[1
,2
]}

Sun, Yong ^{[1
]}

Li, Yongjian ^{[1
,2
]}

Shen, Ruowu ^{[1
]}

Ni, Hongli ^{[1
]}

Hu, Dejian ^{[2
]}

机构：

[1] Qingdao Univ, Coll Med, Fac Pharm, Qingdao 266021, Shandong, Peoples R China

[2] Weifang Peoples Hosp, Dept Pharm Intravenous Admixture Serv, Weifang, Shandong, Peoples R China

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2012年 / 40卷 / 1-2期

关键词：

supercritical fluid; sirolimus; liposome; RESS; INDOMETHACIN; TECHNOLOGY;

D O I：

10.3109/10731199.2011.585618

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.

引用

页码：62 / 65

页数：4

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