Support of Tumor Endothelial Cells by Chemokine Receptors

被引:50
作者
Salazar, Nicole [1 ]
Zabel, Brian A. [2 ]
机构
[1] San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto Vet Inst Res, Palo Alto, CA 94304 USA
关键词
chemokine receptor; chemoattractant; endothelial cell; tumor vasculature; tumor microenvironment; TRANSENDOTHELIAL MIGRATION; PROGENITOR CELLS; I-TAC; CXCR7; ANGIOGENESIS; EXPRESSION; GROWTH; AXIS; STEM; METASTASIS;
D O I
10.3389/fimmu.2019.00147
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor burden, although loss of efficacy due to acquisition of resistance mechanisms is common. Here we review mechanisms by which tumor endothelial cells (TEC) utilize chemokine receptors to support tumor progression. We illustrate how chemokine receptors support and may serve as functional markers of the diverse TEC population. We focus on ACKR1 (DARC), ACKR3 (CXCR7), CXCR4, and CCR2, as these are the best studied chemokine receptors in TEC: and suggest that targeting these receptors on the tumor vasculature may prove efficacious in slowing or reversing tumor growth. We also mention CXCR2 and CXCR3 as important mediators or tumor angiogenesis, given their distinct roles with angiogenic and angiostatic chemokines, respectively.
引用
收藏
页数:9
相关论文
共 90 条
[71]  
Sun Zhengda, 2018, Oncotarget, V9, P10945, DOI 10.18632/oncotarget.23760
[72]   Downregulation of CXCR7 inhibits proliferative capacity and stem cell-like properties in breast cancer stem cells [J].
Tang, Xin ;
Li, Xiang ;
Li, Zitao ;
Liu, Yunshuang ;
Yao, Lihong ;
Song, Shuang ;
Yang, Hongyan ;
Li, Caijuan .
TUMOR BIOLOGY, 2016, 37 (10) :13425-13433
[73]   Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues [J].
Thiriot, Aude ;
Perdomo, Carolina ;
Cheng, Guiying ;
Novitzky-Basso, Igor ;
McArdle, Sara ;
Kishimoto, Jamie K. ;
Barreiro, Olga ;
Mazo, Irina ;
Triboulet, Robinson ;
Ley, Klaus ;
Rot, Antal ;
von Andrian, Ulrich H. .
BMC BIOLOGY, 2017, 15
[74]   The role of CXC chemokines and their receptors in cancer [J].
Vandercappellen, Jo ;
Van Damme, Jo ;
Struyf, Sofie .
CANCER LETTERS, 2008, 267 (02) :226-244
[75]   Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis [J].
Vegran, Frederique ;
Boidot, Romain ;
Michiels, Carine ;
Sonveaux, Pierre ;
Feron, Olivier .
CANCER RESEARCH, 2011, 71 (07) :2550-2560
[76]   Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats [J].
Walters, M. J. ;
Ebsworth, K. ;
Berahovich, R. D. ;
Penfold, M. E. T. ;
Liu, S-C ;
Al Omran, R. ;
Kioi, M. ;
Chernikova, S. B. ;
Tseng, D. ;
Mulkearns-Hubert, E. E. ;
Sinyuk, M. ;
Ransohoff, R. M. ;
Lathia, J. D. ;
Karamchandani, J. ;
Kohrt, H. E. K. ;
Zhang, P. ;
Powers, J. P. ;
Jaen, J. C. ;
Schall, T. J. ;
Merchant, M. ;
Recht, L. ;
Brown, J. M. .
BRITISH JOURNAL OF CANCER, 2014, 110 (05) :1179-1188
[77]   Glioblastoma stem-like cells give rise to tumour endothelium [J].
Wang, Rong ;
Chadalavada, Kalyani ;
Wilshire, Jennifer ;
Kowalik, Urszula ;
Hovinga, Koos E. ;
Geber, Adam ;
Fligelman, Boris ;
Leversha, Margaret ;
Brennan, Cameron ;
Tabar, Viviane .
NATURE, 2010, 468 (7325) :829-U128
[78]   Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway [J].
Wolf, Monika Julia ;
Hoos, Alexandra ;
Bauer, Judith ;
Boettcher, Steffen ;
Knust, Markus ;
Weber, Achim ;
Simonavicius, Nicole ;
Schneider, Christoph ;
Lang, Matthias ;
Stuerzl, Michael ;
Croner, Roland S. ;
Konrad, Andreas ;
Manz, Markus G. ;
Moch, Holger ;
Aguzzi, Adriano ;
van Loo, Geert ;
Pasparakis, Manolis ;
Prinz, Marco ;
Borsig, Lubor ;
Heikenwalder, Mathias .
CANCER CELL, 2012, 22 (01) :91-105
[79]   Vascular CXCR4 Expression Promotes Vessel Sprouting and Sensitivity to Sorafenib Treatment in Hepatocellular Carcinoma [J].
Xu, Jing ;
Liang, Jing ;
Meng, Ya-Ming ;
Yan, Jing ;
Yu, Xing-Juan ;
Liu, Chao-Qun ;
Xu, Li ;
Zhuang, Shi-Mei ;
Zheng, Limin .
CLINICAL CANCER RESEARCH, 2017, 23 (15) :4482-4492
[80]   CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property [J].
Yamada, Kenji ;
Maishi, Nako ;
Akiyama, Kosuke ;
Alam, Mohammad Towfik ;
Ohga, Noritaka ;
Kawamoto, Taisuke ;
Shindoh, Masanobu ;
Takahashi, Norihiko ;
Kamiyama, Toshiya ;
Hida, Yasuhiro ;
Taketomi, Akinobu ;
Hida, Kyoko .
INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (12) :2825-2836