Prevention of peritoneal adhesions: A promising role for gene therapy

被引：42

作者：

Atta, Hussein M. ^{[1
]}

机构：

[1] Menia Univ, Dept Surg, Fac Med, El Minia 61519, Egypt

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 46期

关键词：

Peritoneal adhesions; Tissue plasminogen activator; Gene therapy; Plasminogen activator inhibitor; Tissue inhibitor of metalloproteinase; Transforming growth factor beta; TISSUE-PLASMINOGEN-ACTIVATOR; GROWTH-FACTOR-BETA; CARBON-DIOXIDE PNEUMOPERITONEUM; MATRIX-METALLOPROTEINASE MMP-1; CONTROLLED RESPIRATORY SUPPORT; ALPHA TNF-ALPHA; MESOTHELIAL CELLS; POSTOPERATIVE ADHESIONS; LAPAROSCOPIC SURGERY; TRANSFORMING GROWTH-FACTOR-BETA-1;

D O I：

10.3748/wjg.v17.i46.5049

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Adhesions are the most frequent complication of abdominopelvic surgery, yet the extent of the problem, and its serious consequences, has not been adequately recognized. Adhesions evolved as a life-saving mechanism to limit the spread of intraperitoneal inflammatory conditions. Three different pathophysiological mechanisms can independently trigger adhesion formation. Mesothelial cell injury and loss during operations, tissue hypoxia and inflammation each promotes adhesion formation separately, and potentiate the effect of each other. Studies have repeatedly demonstrated that interruption of a single pathway does not completely prevent adhesion formation. This review summarizes the pathogenesis of adhesion formation and the results of single gene therapy interventions. It explores the promising role of combinatorial gene therapy and vector modifications for the prevention of adhesion formation in order to stimulate new ideas and encourage rapid advancements in this field. (C) 2011 Baishideng. All rights reserved.

引用

页码：5049 / 5058

页数：10

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