Personal care products: Demographic characteristics and maternal hormones in pregnant women from Puerto Rico

被引:13
作者
Rivera-Nunez, Zorimar [1 ,2 ]
Ashrap, Pahriya [3 ]
Barrett, Emily S. [1 ,2 ]
Llanos, Adana A. M. [1 ,4 ]
Watkins, Deborah J. [3 ]
Cathey, Amber L. [3 ]
Velez-Vega, Carmen M. [5 ]
Rosario, Zaira [6 ]
Cordero, Jose F. [6 ]
Alshawabkeh, Akram [7 ]
Meeker, John D. [3 ]
机构
[1] Rutgers Sch Publ Hlth, Dept Biostat & Epidemiol, Piscataway, NJ USA
[2] Rutgers State Univ, Environm & Occupat Hlth Sci Inst, Piscataway, NJ USA
[3] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
[4] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA
[5] Univ Puerto Rico, Grad Program Publ Hlth, UPR Med Sci Campus, San Juan, PR USA
[6] Univ Georgia, Dept Epidemiol & Biostat, Athens, GA 30602 USA
[7] Northeastern Univ, Coll Engn, Boston, MA 02115 USA
关键词
Personal care products; Maternal hormones; Pregnancy; Endocrine disruptors; Exposure measurement; URINARY CONCENTRATIONS; BREAST-CANCER; PRETERM BIRTH; EXPOSURE; PARABENS; HAIR; VARIABILITY; PREDICTORS; RISK; PROGESTERONE;
D O I
10.1016/j.envres.2021.112376
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Personal care products (PCPs) refer to a wide variety of items commonly characterized as health or beauty products. PCPs contain a number of ingredients, often including a wide range of endocrine disrupting chemicals such as phthalates and parabens. The present study examines the association between self-reported PCP use and prenatal sex-steroids and thyroid hormones levels in women from Puerto Rico. We recruited pregnant women (n = 1070) through the Puerto Rico PROTECT Cohort and collected blood, demographic and pregnancy-related data at recruitment and subsequent visits. PCP use in the 48-h preceding the blood sample was collected through self-reported questionnaires. Nine hormones (corticotropin-releasing hormone [CRH], sex-hormone binding globulin [SHBG], estriol [E3], progesterone, testosterone, thyroid-stimulating hormone [TSH], total triiodothyronine [T3], total thyroxine [T4], and free thyroxine [fT4]) were measured in maternal serum samples at two points during pregnancy. Linear mixed models with random intercepts were used to examine associations between PCP use and serum hormone levels. Use of cosmetics significantly increased with age, household income and education level (p < 0.01). Use of hair products, such as hair dyes and bleach, relaxers, and mousse, was associated with lower levels of all sex steroid hormones compared to non-use: SHBG (%Delta = -7.1, 95%CI: -12.4,-1.8), E3 (%Delta = -23.2, 95%CI: -32.2,-13.0), progesterone (%Delta = -21.5, 95%CI: -29.4,-12.9) and testosterone (%Delta = -21.5, 95%CI: -33.1,-7.8) adjusted for maternal age, education and pre-pregnancy body mass index. Our findings suggest that household income and education level influence PCP use among pregnant women in this study. Use of certain hair products was associated with lower concentrations of sex steroid hormones. Although there are limitations to questionnaire data, characterizing PCP use is inexpensive and may represent exposure from multiple classes of chemicals, including chemicals that may not specifically appear on product labels and/or have not been tested for endocrine disrupting potential, making it a useful complement to chemical biomarker data.
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页数:9
相关论文
共 67 条
[1]   Size at birth predicts age at menarche [J].
Adair, LS .
PEDIATRICS, 2001, 107 (04) :E59
[2]  
ADVIA, 08700387 ADVIA
[3]  
ADVIA, 05476206 ADVIA
[4]  
ADVIA, 06490106 ADVIA
[5]  
ADVIA, 06520781 ADVIA
[6]  
ADVIA, 09236439 ADVIA
[7]   A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort [J].
Aker, Amira M. ;
Ferguson, Kelly K. ;
Rosario, Zaira Y. ;
Mukherjee, Bhramar ;
Alshawabkeh, Akram N. ;
Calafat, Antonia M. ;
Cordero, Jose F. ;
Meeker, John D. .
ENVIRONMENTAL HEALTH, 2019, 18 (1)
[8]   Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study [J].
Aker, Amira M. ;
Johns, Lauren ;
McElrath, Thomas F. ;
Cantonwine, David E. ;
Mukherjee, Bhramar ;
Meeker, John D. .
ENVIRONMENT INTERNATIONAL, 2018, 113 :341-349
[9]   Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women [J].
Aker, Amira M. ;
Watkins, Deborah J. ;
Johns, Lauren E. ;
Ferguson, Kelly K. ;
Soldin, Offie P. ;
Del Toro, Liza V. Anzalota ;
Alshawabkeh, Akram N. ;
Cordero, Jose F. ;
Meeker, John D. .
ENVIRONMENTAL RESEARCH, 2016, 151 :30-37
[10]  
[Anonymous], 1946, Mathematical Methods of Statistics