Segregation of chromosomes in sperm of Robertsonian translocation carriers

被引：57

作者：

Roux, C ^{[1
]}

Tripogney, C

Morel, F

Joanne, C

Fellmann, F

Clavequin, MC

Bresson, JL

机构：

[1] CHU St Jacques, Serv Genet Histol Biol Dev & Reprod, EA 3185, IFR 133,IBCT,CECOS Franche Comte Bourgogne, F-25030 Besancon, France

[2] Univ Bretagne Occidentale, CHU Morvan, Serv Cytogenet Cytol & Biol Reprod, Lab Histol Embryol & Cytogenet,Fac Med & Sci Sant, Brest, France

来源：

CYTOGENETIC AND GENOME RESEARCH | 2005年 / 111卷 / 3-4期

关键词：

D O I：

10.1159/000086902

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Robertsonian translocations are the most frequent structural chromosomal abnormalities in humans and can affect fertility, with various degrees of sperm alterations in men; or the pregnancy outcome of the carriers. The studies on meiotic segregation of chromosomes in sperm of Robertsonian translocation males find a majority of normal or balanced spermatozoa for the chromosomes related to the translocation ( mean 85.42%; range 60 - 96.60%). Furthermore, recent studies suggest an interchromosomal effect. Studies on spermatozoa from translocation carriers, and in mouse models help the comprehension of the meiotic segregation mechanisms. Results of meiotic segregation analysis in man could be integrated in genetic counselling especially when assisted reproductive technology is required. Copyright (c) 2005 S. Karger AG, Basel.

引用

页码：291 / 296

页数：6

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