The effect of low-dose Cordyceps on ischemia-reperfusion of the in rats

被引:0
作者
Aydogdu, Bahattin [1 ]
Basuguy, Erol [1 ]
Arslan, Serkan [1 ]
Azizoglu, Mustafa [1 ]
Ibiloglu, Ibrahim [2 ]
Kaplan, Ibrahim [3 ]
Aydogdu, Gulay [2 ]
Hanifi-Okur, Mehmet [1 ]
机构
[1] Dicle Univ, Fac Med, Dept Pediat Surg, Diyarbakir, Turkey
[2] Dicle Univ, Fac Med, Dept Pathol, Diyarbakir, Turkey
[3] Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey
来源
CIRUGIA Y CIRUJANOS | 2022年 / 90卷
关键词
Cordyceps; Ischemia-reperfusion injury; Kidney; RENAL ISCHEMIA/REPERFUSION INJURY; INFLAMMATION;
D O I
10.24875/CIRU.22000303
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.
引用
收藏
页码:69 / 74
页数:6
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