The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health

被引:56
作者
Clemente-Postigo, Mercedes [1 ]
Tinahones, Alberto [2 ]
El Bekay, Rajaa [3 ,4 ]
Malagon, Maria M. [1 ,4 ]
Tinahones, Francisco J. [2 ,4 ]
机构
[1] Univ Cordoba, Reina Sofia Univ Hosp, Dept Cell Biol Physiol & Immunol, Inst Maimonides Invest Biomed Cordoba IMIBIC, Edificio IMIBIC,Ave Menendez Pidal S-N, Cordoba 14004, Spain
[2] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Campus Teatinos S-N, Malaga 29010, Spain
[3] Univ Malaga, Unidad Gest Clin Endocrinol & Nutr, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, Campus Teatinos S-N, Malaga 29010, Spain
[4] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red CIBER Fisiopatol Obesidad &, Madrid 28029, Spain
关键词
adipose tissue; adipocyte; autophagy; obesity; diabetes; metabolism; BINDING PROTEIN-BETA; PREADIPOCYTE DIFFERENTIATION; ADIPOGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; CARGO RECOGNITION; CLONAL EXPANSION; DIETARY-FAT; OBESE MICE; ADIPOCYTE;
D O I
10.3390/metabo10050179
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.
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页数:29
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