Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts

被引：45
作者：
Jia, Z-L [1 ,2 ]
Shi, B. [1 ,2 ]
Chen, C-H [1 ,2 ]
Shi, J-Y [1 ,2 ]
Wu, J. [1 ,2 ]
Xu, X. [1 ,2 ]
机构：
[1] Sichuan Univ, Dept Cleft Lip & Palate, W China Coll Stomatol, Chengdu 610041, Peoples R China
[2] Sichuan Univ, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
来源：
ORAL DISEASES | 2011年 / 17卷 / 06期
基金：
中国国家自然科学基金;
关键词：
non-syndromic oral clefts; cleft lip with or without palate; cleft palate only; logistic regression analysis; ORAL CLEFTS; ALCOHOL-CONSUMPTION; OCCUPATIONAL-EXPOSURE; PALATE; LIP; SMOKING; POPULATION; ANOMALIES;
D O I：
10.1111/j.1601-0825.2011.01810.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
OBJECTIVE: To explore the risk factors of non-syndromic orofacial clefts. SUBJECTS AND METHODS: A case-control study was conducted in China, 537 infants born with non-syndromic cleft lip with/without cleft palate, 176 infants born with cleft palate (CP), and 221 normal controls were recruited to participate in a questionnaire based study to identify risk factors related to maternal nutrition. RESULTS: Single-factor Chi-square analysis identified 12 factors as significantly related to non-syndromic orofacial clefts (P < 0.05). Multiple logistic regression showed five of these factors were associated with non-syndromic orofacial clefts, male gender and maternal passive smoking during early pregnancy were risk factors for non-syndromic orofacial clefts (OR = 1.86 and 11.42; 95% CI: 2.28-2.69 and 6.87-19.00, respectively), whereas maternal weight gain during pregnancy and folic acid supplementation during early pregnancy were protective (OR = 0.15 and 0.67; 95% CI: 0.034-0.63 and 0.44-1.00, respectively). CONCLUSIONS: Our data may provide references for cleft lip and CP prevention programs, and counseling programs in China. Oral Diseases (2011) 17, 584-589
引用
收藏
页码：584 / 589
页数：6
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