Acceptability and efficacy of vaginal self-sampling for genital infection and bacterial vaginosis: A cross-sectional study

被引:10
作者
Camus, Claire [1 ,2 ]
Penaranda, Guillaume [1 ]
Khiri, Hacene [1 ]
Camiade, Sabine [3 ]
Molet, Lucie [1 ]
Lebsir, Melissa [3 ]
Plauzolles, Anne [1 ]
Chiche, Laurent [4 ]
Blanc, Bernard [5 ]
Quarello, Edwin [6 ,7 ]
Halfon, Philippe [1 ,4 ]
机构
[1] Alphabio Biogrp, Lab Europeen, Clin Res & R&D Dept, Marseille, France
[2] Hop Purpan, CHU Toulouse, FCRIN INSERM US015, Toulouse, France
[3] Lab Europeen Alphabio Biogrp, Bacteriol Dept, Marseille, France
[4] Hop Europeen Marseille, Infect & Internal Med Dept, Marseille, France
[5] Hop Europeen Marseille, Gynecol Dept, Marseille, France
[6] St Joseph Hosp, Prenatal Screening & Diagnost Unit, Obstet & Gynecol Dept, Marseille, France
[7] Image2 Ctr, Marseille, France
来源
PLOS ONE | 2021年 / 16卷 / 11期
关键词
GROUP-B STREPTOCOCCUS; CHLAMYDIA-TRACHOMATIS; TRICHOMONAS-VAGINALIS; SOCIOECONOMIC GROUPS; SPECIMEN COLLECTION; PATIENT PREFERENCE; GRAM STAIN; WOMEN; SWABS; DIAGNOSIS;
D O I
10.1371/journal.pone.0260021
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background & aim Screening for genital infection (GI) such as bacterial vaginosis (BV) and yeast infection, for sexually transmitted infection (STI), and for asymptomatic carriage of group B streptococcus (GBS) in pregnant women are common reason for medical appointments. The diagnosis and control of GIs, STIs, and GBS are major issues, for fertility and overall well-being of affected women. Conventional testing is performed using vaginal/cervical classical sampling (VCS); this procedure requires pelvic examination performed by health care professionals which raises concerns among women. Vaginal-self-sampling (VSS), as an alternative to VCS, might capture more women. The aim was first to show non-inferiority of VSS compared with VCS to screen for GIs, STIs, and GBS; second to determine the feasibility of VSS. Methods VSS and VCS from 1027 women were collected by health care professionals and simultaneously carried out on each patient. GIs, STIs, and GBS were systematically screened in both paired VSS and VCS samples. Non-inferiority of VSS compared with VCS was assessed using z statistic for binomial proportions. Results Prevalence of GIs were 39.7% using VSS and 38.1% using VCS (p = 0.0016). Prevalence of STIs was 8.5% (VSS) vs 8.1% (VCS) (p = 0.0087). Prevalence of GBS was 13.4% (VSS) and 11.5% (VCS) (p = 0.0001). Most participants (84%) recommended the use of VSS. Conclusions This study shows that VSS was not inferior to VCS for the detection of GIs, STIs, and GBS. This study provides evidence that VSS can be used as a universal specimen for detection of lower genital tract infections in women.
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页数:13
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