Characterization of cytolethal distending toxin genes and expression in Shiga toxin-producing Escherichia coli strains of non-O157 serogroups

被引：95

作者：

Bielaszewska, M

Fell, M

Greune, L

Prager, R

Fruth, A

Tschäpe, H

Schmidt, MA

Karch, H

机构：

[1] Univ Klinikum Munster, Inst Hyg, D-48149 Munster, Germany

[2] Univ Munster, Inst Infektol, ZMBE, D-48149 Munster, Germany

[3] Robert Koch Inst, D-38855 Wernigerode, Germany

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期

关键词：

D O I：

10.1128/IAI.72.3.1812-1816.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We identified cytolethal distending toxin and its gene (cdt) in 17 of 340 non-O157 Shiga toxin-producing Eschetichia coli (STEC) strains (serotypes O73:H18,O91:H21, O113:H21, and O153:H18), all of which were eae negative. cdt is either chromosomal and homologous to cdt-V (serotypes O73:H18, O91021, and O113:R21) or plasmidborne and identical to cdt-III (serotype O153:H18). Among eae-negative STEC, cdt was associated with disease (P = 0.003).

引用

收藏

页码：1812 / 1816

页数：5

相关论文

共 24 条

[1] Controlled study of cytolethal distending toxin-producing Escherichia coli infections in Bangladeshi children [J].

Albert, MJ ;

Faruque, SM ;

Faruque, ASG ;

Bettelheim, KA ;

Neogi, PKB ;

Bhuiyan, NA ;

Kaper, JB .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (03) :717-719

[2] Clonal groups of enteropathogenic Escherichia coli isolated in case-control studies of diarrhoea in Bangladesh [J].

Ansaruzzaman, M ;

Albert, MJ ;

Nahar, S ;

Byun, R ;

Katouli, M ;

Kühn, I ;

Möllby, R .

JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 49 (02) :177-185

[3] Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans [J].

Boerlin, P ;

McEwen, SA ;

Boerlin-Petzold, F ;

Wilson, JB ;

Johnson, RP ;

Gyles, CL .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :497-503

[4] PCR for detection of cdt-III and the relative frequencies of cytolethal distending toxin variant-producing Escherichia coli isolates from humans and cattle [J].

Clark, CG ;

Johnson, ST ;

Easy, RH ;

Campbell, JL ;

Rodgers, FG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (07) :2671-2674

[5] The cytolethal distending toxins induce DNA damage and cell cycle arrest [J].

Cortes-Bratti, X ;

Frisan, T ;

Thelestam, M .

TOXICON, 2001, 39 (11) :1729-1736

[6] DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest [J].

Elwell, CA ;

Dreyfus, LA .

MOLECULAR MICROBIOLOGY, 2000, 37 (04) :952-963

[7] Shiga toxin 1c-producing Escherichia coli strains:: Phenotypic and genetic characterization and association with human disease [J].

Friedrich, AW ;

Borell, J ;

Bielaszewska, M ;

Fruth, A ;

Tschäpe, H ;

Karch, H .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (06) :2448-2453

[8] Escherichia coli harboring shiga toxin 2 gene variants:: frequency and association with clinical symptoms [J].

Friedrich, AW ;

Bielaszewska, M ;

Zhang, WL ;

Pulz, M ;

Kuczius, T ;

Ammon, A ;

Karch, H .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (01) :74-84

[9] Production of cytolethal distending toxin and other virulence characteristics of Escherichia coli strains of serogroup O86 [J].

Ghilardi, ACR ;

Gomes, TAT ;

Trabulsi, LR .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2001, 96 (05) :703-708

[10] CLONING AND NUCLEOTIDE SEQUENCING OF VERO TOXIN 2 VARIANT GENES FROM ESCHERICHIA-COLI O91-H21 ISOLATED FROM A PATIENT WITH THE HEMOLYTIC UREMIC SYNDROME [J].

ITO, H ;

TERAI, A ;

KURAZONO, H ;

TAKEDA, Y ;

NISHIBUCHI, M .

MICROBIAL PATHOGENESIS, 1990, 8 (01) :47-60