Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence

被引：150

作者：

Bos, Daniel ^{[1
,2
,3
]}

Wolters, Frank J. ^{[2
,3
]}

Darweesh, Sirwan K. L. ^{[2
,3
]}

Vernooij, Meike W. ^{[1
,2
]}

de Wolf, Frank ^{[4
,5
]}

Ikram, M. Arfan ^{[1
,2
,6
]}

Hofman, Albert ^{[3
]}

机构：

[1] Erasmus MC Univ, Med Ctr Rotterdam, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[2] Erasmus MC Univ, Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands

[3] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[4] Janssen Prevent Ctr, Leiden, Netherlands

[5] Imperial Coll London, Sch Publ Hlth, Fac Med, London, England

[6] Erasmus MC Univ, Med Ctr Rotterdam, Dept Neurol, Rotterdam, Netherlands

来源：

ALZHEIMERS & DEMENTIA | 2018年 / 14卷 / 11期

关键词：

Cerebral small vessel disease; White matter hyperintensities; Covert brain infarcts; Microbleeds; Imaging; Dementia; WHITE-MATTER HYPERINTENSITIES; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; PERIVASCULAR SPACES; BRAIN INFARCTS; MICROBLEEDS; STROKE; PROGRESSION; PREDICTORS; MECHANISMS;

D O I：

10.1016/j.jalz.2018.04.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Cerebral small vessel disease is increasingly linked to dementia. Methods: We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all-dementia or Alzheimer's disease and performed meta-analyses. Results: We identified 11 studies on white matter hyperintensities, covert brain infarcts, or cerebral microbleeds with risk of all-dementia or Alzheimer's disease. Pooled analyses showed an association of white matter hyperintensity volume and a borderline association of covert brain infarcts with risk of all-dementia (hazard ratio: 1.39 [95% confidence interval: 1.00; 1.94], N = 3913, and 1.47 [95% confidence interval: 0.97; 2.22], N = 8296). Microbleeds were not statistically significantly associated with an increased risk of all-dementia (hazard ratio: 1.25 [95% confidence interval: 0.66; 2.38], N = 8739). Discussion: White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population. However, studies are warranted to further determine the role of markers of cerebral small vessel disease in dementia. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1482 / 1492

页数：11

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