Refining rodent models of spinal cord injury

被引：51

作者：

Lilley, Elliot ^{[1
]}

Andrews, Melissa R. ^{[2
]}

Bradbury, Elizabeth J. ^{[3
]}

Elliott, Heather ^{[4
]}

Hawkins, Penny ^{[1
]}

Ichiyama, Ronaldo M. ^{[5
]}

Keeley, Jo ^{[6
]}

Michael-Titus, Adina T. ^{[7
]}

Moon, Lawrence D. F. ^{[3
]}

Pluchino, Stefano ^{[6
]}

Riddell, John ^{[8
]}

Ryder, Kathy ^{[4
]}

Yip, Ping K. ^{[7
]}

机构：

[1] Royal Soc Prevent Cruelty Anim, Res Anim Dept, Wilberforce Way, Horsham RH13 9RS, W Sussex, England

[2] Univ Southampton, Biol Sci, 3059,Life Sci Bldg 85, Southampton SO17 1BJ, Hants, England

[3] Kings Coll London, Wolfson Ctr Age Related Dis Inst Psychiat Psychol, Regenerat Grp, Guys Campus, London SE1 1UL, England

[4] Anim Sci Res Unit, 14th Floor,Lunar House,40 Wellesley Rd, Croydon CR9 2BY, England

[5] Univ Leeds, Fac Biol Sci, Sch Biomed Sci, Leeds, W Yorkshire, England

[6] Univ Cambridge, Univ Biomed Serv, Greenwich House,Madingley Rd, Cambridge CB3 0TX, England

[7] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Neurosci Surg & Trauma, 4 Newark St, London E1 2AT, England

[8] Univ Glasgow, Coll Med Vet & Life Sci, Inst Neurosci & Psychol, Spinal Cord Grp, Glasgow G12 8QQ, Lanark, Scotland

来源：

EXPERIMENTAL NEUROLOGY | 2020年 / 328卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Animal model; Animal welfare; Refinement; Three Rs; Spinal cord injury; Spinal contusion; Spinal transection; Paralysis; Translational research; Regeneration; Tissue repair; MECHANICAL HYPERSENSITIVITY; ANIMAL-MODELS; RAT MODEL; 3; RS; RECOVERY; AMITRIPTYLINE; EPIDEMIOLOGY; SENSORIMOTOR; ANXIETY; WELFARE;

D O I：

10.1016/j.expneurol.2020.113273

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

引用

页数：12

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