Discovery and SAR of Org 24598 - A selective glycine uptake inhibitor

被引：92

作者：

Brown, A

Carlyle, I

Clark, J

Hamilton, W

Gibson, S ^{[1
]}

McGarry, G

McEachen, S

Rae, D

Thorn, S

Walker, G

机构：

[1] Organon Res & Dev Grp, Dept Med Chem, Newhouse ML1 5SH, Lanark, Scotland

[2] Organon Res & Dev Grp, Dept Pharmacol, Newhouse ML1 5SH, Lanark, Scotland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)00355-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2007 / 2009

页数：3

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