The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials

被引：3

作者：

Park, So Young ^{[1
]}

Yoo, Kwang Ha ^{[2
]}

Park, Yong Bum ^{[3
]}

Rhee, Chin Kook ^{[4
]}

Park, Jinkyeong ^{[5
]}

Park, Hye Yun ^{[6
]}

Hwang, Yong Il ^{[7
]}

Park, Dong Ah ^{[8
]}

Sim, Yun Su ^{[9
]}

机构：

[1] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[2] Konkuk Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[3] Hallym Univ, Kandong Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea

[4] Catholic Univ Korea, Coll Med, Div Pulm Allergy & Crit Care Med, Seoul St Marys Hosp,Dept Internal Med, Seoul, South Korea

[5] Dongguk Univ, Coll Med, Dept Internal Med, Div Pulm, Seoul, South Korea

[6] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Pulm & Crit Care Med,Dept Med, Seoul, South Korea

[7] Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Anyang, South Korea

[8] Natl Evidence Based Healthcare Collaborating Agcy, Off Hlth Technol Assessment Res, Div Healthcare Technol Assessment Res, Seoul, South Korea

[9] Hallym Univ, Kangnam Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Dept Internal Med, 1 Singil Ro, Seoul 07441, South Korea

来源：

TUBERCULOSIS AND RESPIRATORY DISEASES | 2022年 / 85卷 / 01期

关键词：

Noninvasive Positive-Pressure Ventilation; Chronic Obstructive Pulmonary Disease; Mortality; STABLE HYPERCAPNIC COPD; RESPIRATORY-FAILURE; OXYGEN-THERAPY; MULTICENTER;

D O I：

10.4046/trd.2021.0062

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: We evaluated the long-term effects of domiciliary noninvasive positive-pressure ventilation (NIPPV) used to treat patients with chronic obstructive pulmonary disease (COPD). Methods: Databases were searched to identify randomized controlled trials of COPD with NIPPV for longer than 1 year. Mortality rates were the primary outcome in this meta-analysis. The eight trials included in this study comprised data from 913 patients. Results: The mortality rates for the NIPPV and control groups were 29% (118/414) and 36% (151/419), suggesting a statistically significant difference (risk ratio [RR], 0.79; 95% confidence interval [CI], 0.65-0.95). Mortality rates were reduced with NIPPV in four trials that included stable COPD patients. There was no difference in admission, acute exacerbation and quality of life between the NIPPV and control groups. There was no significant difference in withdrawal rates between the two groups (RR, 0.99; 95% CI, 0.72-1.36; p=0.94). Conclusion: Maintaining long-term nocturnal NIPPV for more than 1 year, especially in patients with stable COPD, decreased the mortality rate, without increasing the withdrawal rate compared with long-term oxygen treatment.

引用

页码：47 / 55

页数：9

共 21 条

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