A Systematic Review of Ketamine for Complex Regional Pain Syndrome

被引：36

作者：

Connolly, Sara B. ^{[1
]}

Prager, Joshua P. ^{[2
,3
,4
]}

Harden, R. Norman ^{[1
,5
]}

机构：

[1] Rehabil Inst Chicago, Ctr Pain Studies, Chicago, IL 60611 USA

[2] UCLA Med Plaza, CRPS, Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Internal Med, Los Angeles, CA 90095 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA

来源：

PAIN MEDICINE | 2015年 / 16卷 / 05期

关键词：

Ketamine; Complex Regional Pain Syndrome; Analgesic; N-Methyl-D-Aspartate Antagonists; METHYL-D-ASPARTATE; SYNDROME TYPE-I; POSTHERPETIC NEURALGIA; NEUROPATHIC PAIN; DOUBLE-BLIND; OPEN-LABEL; EFFICACY; MANAGEMENT; ANTAGONISTS; INFUSION;

D O I：

10.1111/pme.12675

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

ObjectiveThis systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine. MethodsThe search was conducted utilizing the databases Medline, Embase and the Cochrane Central Registry of Controlled Trials. All relevant articles were systematically reviewed. ResultsThe search yielded 262 articles, 45 of which met the inclusion/exclusion criteria. Of those included, 6 were reviews, 5 were randomized placebo-controlled trials, 13 were observational studies, and 21 were case reports. ConclusionThere is no high quality evidence available evaluating the efficacy of ketamine for CRPS and all manuscripts examined in this review were of moderate to low quality. Therefore, we conclude there is currently only weak evidence supporting the efficacy of ketamine for CRPS, yet there is clearly a rationale for definitive study.

引用

页码：943 / 969

页数：27

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