Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease

被引:1
作者
Naschitz, JE
Bejar, J
Mogilner, J
Misselevich, I
Steiner, Z
Eldar, S
Yeshurun, D
Boss, JH
机构
[1] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Pathol, IL-31048 Haifa, Israel
[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31048 Haifa, Israel
[3] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Internal Med A, IL-31048 Haifa, Israel
[4] Technion Israel Inst Technol, Bnai Zion Med Ctr, Dept Surg, IL-31048 Haifa, Israel
关键词
fasciitis-panniculitis; lipodermatosclerosis; lipase injection-induced damage of subcutaneous fat tissue; ligation of femoral and saphenous veins; experimental model;
D O I
10.1016/S0923-1811(98)00042-5
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The authors studied the effect of ligation of the femoral and saphenous veins on the evolution of lipase injection-induced subcutaneous fibrosis and inflammation in the pars' hindlimbs. The superficial muscular fascia was thickened and the number of veins was increased 3 days and 3 weeks after vein ligation; both abnormalities disappeared 6 weeks postoperatively. Vein ligation did not quantitatively affect fascial thickening or fibrosing panniculitis in hindlimbs injected with lipase 6 weeks prior to sacrifice. The results contradict the proposition that lipase-induced injury of rats' subcutaneous tissues compromised by venous stasis may lead to a persistent chronic inflammation and fibrosis of the subcutaneous-fascial complex duplicating lipodermatosclerosis in man. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:9 / 16
页数:8
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