Insertion of Arynes into Thioureas: A New Amidine Synthesis

被引：86

作者：

Biswas, Kallolmay ^{[1
]}

Greaney, Michael F. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

BENZYNE; AMIDES;

D O I：

10.1021/ol202049v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal pi-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne sigma-insertion into the C-N bond, and represents a new, operationally simple route to functionalized amidines.

引用

页码：4946 / 4949

页数：4

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