Wound epidermis formation and function in urodele amphibian limb regeneration

被引：70

作者：

Campbell, L. J. ^{[1
]}

Crews, C. M. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 01期

关键词：

limb regeneration; cell migration; wound healing; wound epidermis; positional information; blastema; dedifferentiation;

D O I：

10.1007/s00018-007-7433-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.

引用

页码：73 / 79

页数：7

共 57 条

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