Wound epidermis formation and function in urodele amphibian limb regeneration

被引：70

作者：

Campbell, L. J. ^{[1
]}

Crews, C. M. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 01期

关键词：

limb regeneration; cell migration; wound healing; wound epidermis; positional information; blastema; dedifferentiation;

D O I：

10.1007/s00018-007-7433-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon amputation of the urodele limb, the epidermal cells surrounding the amputation plane migrate to heal the wound. The resulting wound epidermis (WE) induces the regeneration process, resulting in blastema formation, cell division, and ultimately repatterning into a new limb. Despite its central role in the initiation of limb regeneration, little is known about how the WE forms. Here we discuss various models of WE formation and the experimental data in support of each.

引用

页码：73 / 79

页数：7

共 57 条

[1] STIMULATION IN CELL-CULTURE OF MESENCHYMAL CELLS OF NEWT LIMB BLASTEMAS BY EDGF-I OR EDGF-II (BASIC OR ACIDIC FGF) [J].

ALBERT, P ;

BOILLY, B ;

COURTY, J ;

BARRITAULT, D .

CELL DIFFERENTIATION, 1987, 21 (01) :63-68

[2] 2 DISTAL-LESS RELATED HOMEOBOX-CONTAINING GENES EXPRESSED IN REGENERATION BLASTEMAS OF THE NEWT [J].

BEAUCHEMIN, M ;

SAVARD, P .

DEVELOPMENTAL BIOLOGY, 1992, 154 (01) :55-65

[3] ACIDIC FIBROBLAST GROWTH-FACTOR IS PRESENT IN REGENERATING LIMB BLASTEMAS OF AXOLOTLS AND BINDS SPECIFICALLY TO BLASTEMA TISSUES [J].

BOILLY, B ;

CAVANAUGH, KP ;

THOMAS, D ;

HONDERMARCK, H ;

BRYANT, SV ;

BRADSHAW, RA .

DEVELOPMENTAL BIOLOGY, 1991, 145 (02) :302-310

[4] Patterning mechanisms controlling vertebrate limb development [J].

Capdevila, J ;

Belmonte, JCI .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 :87-132

[5] EFFECTS OF ROTATION AND POSITIONAL CHANGE OF STUMP TISSUES UPON MORPHOGENESIS OF REGENERATING AXOLOTL LIMB [J].

CARLSON, BM .

DEVELOPMENTAL BIOLOGY, 1975, 47 (02) :269-291

[6]

CARLSON BM, 1974, DEV BIOL, V39, P263, DOI 10.1016/S0012-1606(74)80029-1

[7]

Carlson MRJ, 1998, J EXP ZOOL, V282, P715, DOI 10.1002/(SICI)1097-010X(19981215)282:6<715::AID-JEZ7>3.0.CO

[8]

2-F

[9] A QUANTITATIVE HISTOLOGICAL ANALYSIS OF FORELIMB REGENERATION IN TRITURUS VIRIDESCENS [J].

CHALKLEY, DT .

JOURNAL OF MORPHOLOGY, 1954, 94 (01) :21-70

[10]

CHANDEBOIS R, 1980, DEV GROWTH DIFFER, V22, P693, DOI 10.1111/j.1440-169X.1980.00693.x

← 1 2 3 4 5 6 →