Smads:: Transcriptional activators of TGF-β responses

被引:949
作者
Derynck, R [1 ]
Zhang, Y
Feng, XH
机构
[1] Univ Calif San Francisco, Dept Growth & Dev, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Anat, Cell Biol Program, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Anat, Program Dev Biol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0092-8674(00)81696-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:737 / 740
页数:4
相关论文
共 29 条
[1]   Smad4 and FAST-1 in the assembly of activin-responsive factor [J].
Chen, X ;
Weisberg, E ;
Fridmacher, V ;
Watanabe, M ;
Naco, G ;
Whitman, M .
NATURE, 1997, 389 (6646) :85-89
[2]   A transcriptional partner for MAD proteins in TGF-beta signalling [J].
Chen, X ;
Rubock, MJ ;
Whitman, M .
NATURE, 1996, 383 (6602) :691-696
[3]   Determinants of specificity in TGF-β signal transduction [J].
Chen, YG ;
Hata, A ;
Lo, RS ;
Wotton, D ;
Shi, YG ;
Pavletich, N ;
Massagué, J .
GENES & DEVELOPMENT, 1998, 12 (14) :2144-2152
[4]   STATs and gene regulation [J].
Darnell, JE .
SCIENCE, 1997, 277 (5332) :1630-1635
[5]   FUNCTIONAL-ANALYSIS OF THE TRANSFORMING GROWTH-FACTOR-BETA RESPONSIVE ELEMENTS IN THE WAF1/CIP1/P21 PROMOTER [J].
DATTO, MB ;
YU, Y ;
WANG, XF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) :28623-28628
[6]   Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene [J].
Dennler, S ;
Itoh, S ;
Vivien, D ;
ten Dijke, P ;
Huet, S ;
Gauthier, JM .
EMBO JOURNAL, 1998, 17 (11) :3091-3100
[7]   TGF-beta receptor signaling [J].
Derynck, R ;
Feng, XH .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1997, 1333 (02) :F105-F150
[8]   The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation [J].
Feng, XH ;
Zhang, Y ;
Wu, RY ;
Derynck, R .
GENES & DEVELOPMENT, 1998, 12 (14) :2153-2163
[9]   Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 [J].
Hata, A ;
Lo, RS ;
Wotton, D ;
Lagna, G ;
Massague, J .
NATURE, 1997, 388 (6637) :82-87
[10]   TGF-beta signalling from cell membrane to nucleus through SMAD proteins [J].
Heldin, CH ;
Miyazono, K ;
tenDijke, P .
NATURE, 1997, 390 (6659) :465-471