Protective effects of bacterial osmoprotectant ectoine on bovine erythrocytes subjected to staphylococcal alpha-haemolysin

被引：6

作者：

Bownik, Adam ^{[1
]}

Stepniewska, Zofia ^{[2
]}

机构：

[1] John Paul II Catholic Univ Lublin, Fac Biotechnol & Environm Sci, Dept Anim Physiol & Toxicol, PL-20708 Lublin, Poland

[2] John Paul II Catholic Univ Lublin, Fac Biotechnol & Environm Sci, Dept Biochem & Environm Chem, PL-20708 Lublin, Poland

来源：

TOXICON | 2015年 / 99卷

关键词：

Ectoine; Bovine erythrocytes; Alpha-haemolysin; Compatible solutes; Osmoprotectant; COMPATIBLE SOLUTES; OSMOADAPTATION; HYDROXYECTOINE; STABILIZATION; OSMOLYTES; AUREUS;

D O I：

10.1016/j.toxicon.2015.03.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ectoine (ECT) is a bacterial compatible solute with documented protective action however no data are available on its effects on various cells against bacterial toxins. Therefore, we determined the in vitro influence of ECT on bovine erythrocytes subjected to staphylococcal alpha-haemolysin (HlyA). The cells exposed to HlyA alone showed a distinct haemolysis and reduced glutathione (GSH)/oxidised glutathione (GSSG) level, however the toxic effects were attenuated in the combinations of HlyA + ECT suggesting ECT-induced protection of erythrocytes from HlyA. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：130 / 135

页数：6

共 26 条

[11] Extrinsic protein stabilization by the naturally occurring osmolytes β-hydroxyectoine and betaine [J].