Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells

被引：63

作者：

Chakrabarti, Mrinmay ^{[1
]}

Khandkar, Mehrab ^{[1
]}

Banik, Naren L. ^{[2
]}

Ray, Pan K. ^{[1
]}

机构：

[1] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

[2] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

来源：

BRAIN RESEARCH | 2012年 / 1454卷

基金：

美国国家卫生研究院;

关键词：

apoptosis; (-)-epigallocatechin-3-gallate; N-(4-hydroxyphenyl) retinamide; neuroblastoma; oncogenic miRs; tumor suppressor miRs; GLIOBLASTOMA T98G; APOPTOSIS; DIFFERENTIATION; ACTIVATION; MECHANISM; CALPAIN; STRESS; MYCN;

D O I：

10.1016/j.brainres.2012.03.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Malignant neuroblastomas are childhood tumors that remain mostly incurable. We explored efficacy of N-(4-hydroxyphenyl) retinamide (4-HPR) and (-)-epigallocatechin-3-gallate (EGCG) in altering expression of oncogenic microRNAs (OGmiRs) and tumor suppressor miRs (TSmiRs) for controlling growth of human malignant neuroblastoma SK-N-BE2 and IMR-32 cells. Combination of 4-HPR and EGCG most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines. Overexpression of miR-93 and miR-7-1, respectively, decreased and increased efficacy of treatments. Thus, alterations in expression of specific OGmiRs and TSmiRs by 4-HPR and EGCG inhibited growth of malignant neuroblastomas. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：1 / 13

页数：13

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