共 96 条
From bone marrow to microglia: barriers and avenues
被引:125
作者:

Davoust, Nathalie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lyon, U851, INSERM, IFR Biosci, F-69007 Lyon, France Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France

Vuaillat, Carine
论文数: 0 引用数: 0
h-index: 0
机构:
Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France

Androdias, Geraldine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France

Nataf, Serge
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France
机构:
[1] Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France
[2] Univ Lyon, U851, INSERM, IFR Biosci, F-69007 Lyon, France
[3] Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA
关键词:
D O I:
10.1016/j.it.2008.01.010
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Microglia form a unique population of brain-resident macrophages. Although microglia have been involved in multiple disorders of the central nervous system (CNS), the issue of microglial renewal, under normal or pathological conditions, has been controversial. In mice, results from bone marrow chimera studies indicated that microglia are slowly but continuously replenished by bone marrow-derived cells. Moreover, such a microglial turnover was found to be greatly accelerated under multiple neurological conditions. However, recent works questioned the use of irradiation/reconstitution experiments to assess microglial turnover. Based on these different studies, we propose here a re-evaluation of microglia origin(s) in the inflamed CNS. We also discuss the therapeutic perspectives offered by the demonstration of an adult microglial lineage, from bone marrow to brain.
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页码:227 / 234
页数:8
相关论文
共 96 条
[1]
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
[J].
Ajami, Bahareh
;
Bennett, Jami L.
;
Krieger, Charles
;
Tetzlaff, Wolfram
;
Rossi, Fabio M. V.
.
NATURE NEUROSCIENCE,
2007, 10 (12)
:1538-1543

Ajami, Bahareh
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada

Bennett, Jami L.
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada

Krieger, Charles
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada

Tetzlaff, Wolfram
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada

Rossi, Fabio M. V.
论文数: 0 引用数: 0
h-index: 0
机构: Univ British Columbia, Biomed Res Ctr, Vancouver, BC V6T 1Z3, Canada
[2]
MICROGLIAL PROGENITORS WITH A HIGH PROLIFERATIVE POTENTIAL IN THE EMBRYONIC AND ADULT-MOUSE BRAIN
[J].
ALLIOT, F
;
LECAIN, E
;
GRIMA, B
;
PESSAC, B
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1991, 88 (04)
:1541-1545

ALLIOT, F
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE

LECAIN, E
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE

GRIMA, B
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE

PESSAC, B
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE CNRS,CTR BIOL CELLULAIRE,67 MAURICE GUNSBOURG,F-94205 IVRY,FRANCE
[3]
Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein
[J].
Asheuer, M
;
Pflumio, FO
;
Benhamida, S
;
Dubart-Kupperschmitt, A
;
Fouquet, F
;
Imai, Y
;
Aubourg, P
;
Cartier, N
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2004, 101 (10)
:3557-3562

Asheuer, M
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Pflumio, FO
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Benhamida, S
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Dubart-Kupperschmitt, A
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Fouquet, F
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Imai, Y
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Aubourg, P
论文数: 0 引用数: 0
h-index: 0
机构: Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France

Cartier, N
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France Hop St Vincent de Paul, INSERM U561, F-75014 Paris, France
[4]
A SUBPOPULATION OF BONE MARROW-DERIVED MACROPHAGE-LIKE CELLS SHARES A UNIQUE ION CHANNEL PATTERN WITH MICROGLIA
[J].
BANATI, RB
;
HOPPE, D
;
GOTTMANN, K
;
KREUTZBERG, GW
;
KETTENMANN, H
.
JOURNAL OF NEUROSCIENCE RESEARCH,
1991, 30 (04)
:593-600

BANATI, RB
论文数: 0 引用数: 0
h-index: 0
机构: MAX PLANCK INST PSYCHIAT, DEPT NEUROMORPHOL, AM KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY

HOPPE, D
论文数: 0 引用数: 0
h-index: 0
机构: MAX PLANCK INST PSYCHIAT, DEPT NEUROMORPHOL, AM KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY

GOTTMANN, K
论文数: 0 引用数: 0
h-index: 0
机构: MAX PLANCK INST PSYCHIAT, DEPT NEUROMORPHOL, AM KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY

KREUTZBERG, GW
论文数: 0 引用数: 0
h-index: 0
机构: MAX PLANCK INST PSYCHIAT, DEPT NEUROMORPHOL, AM KLOPFERSPITZ 18A, W-8033 MARTINSRIED, GERMANY

论文数: 引用数:
h-index:
机构:
[5]
CYTOTOXICITY OF MICROGLIA
[J].
BANATI, RB
;
GEHRMANN, J
;
SCHUBERT, P
;
KREUTZBERG, GW
.
GLIA,
1993, 7 (01)
:111-118

BANATI, RB
论文数: 0 引用数: 0
h-index: 0
机构:
MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY

GEHRMANN, J
论文数: 0 引用数: 0
h-index: 0
机构:
MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY

SCHUBERT, P
论文数: 0 引用数: 0
h-index: 0
机构:
MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY

KREUTZBERG, GW
论文数: 0 引用数: 0
h-index: 0
机构:
MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY MAX PLANCK INST PSYCHIAT,DEPT NEUROMORPHOL,AM KLOPFERSPITZ 18A,W-8033 MARTINSRIED,GERMANY
[6]
PHAGOCYTIC-ACTIVITY OF MACROPHAGES AND MICROGLIAL CELLS DURING THE COURSE OF ACUTE AND CHRONIC RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
[J].
BAUER, J
;
SMINIA, T
;
WOUTERLOOD, FG
;
DIJKSTRA, CD
.
JOURNAL OF NEUROSCIENCE RESEARCH,
1994, 38 (04)
:365-375

论文数: 引用数:
h-index:
机构:

SMINIA, T
论文数: 0 引用数: 0
h-index: 0
机构:
VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS

WOUTERLOOD, FG
论文数: 0 引用数: 0
h-index: 0
机构:
VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS

DIJKSTRA, CD
论文数: 0 引用数: 0
h-index: 0
机构:
VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS VRIJE UNIV AMSTERDAM,FAC MED,DEPT ANAT,AMSTERDAM,NETHERLANDS
[7]
Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia
[J].
Bechmann, I
;
Goldmann, J
;
Kovac, AD
;
Kwidzinski, E
;
Simbürger, E
;
Naftolin, F
;
Dirnagl, U
;
Nitsch, R
;
Priller, J
.
FASEB JOURNAL,
2005, 19 (01)
:647-+

Bechmann, I
论文数: 0 引用数: 0
h-index: 0
机构:
Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Goldmann, J
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Kovac, AD
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Kwidzinski, E
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Simbürger, E
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Naftolin, F
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Dirnagl, U
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Nitsch, R
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany

Priller, J
论文数: 0 引用数: 0
h-index: 0
机构: Charite, Ctr Anat, Inst Cell Biol & Neurobiol, D-10098 Berlin, Germany
[8]
What is the blood-brain barrier (not)?
[J].
Bechmann, Ingo
;
Galea, Ian
;
Perry, V. Hugh
.
TRENDS IN IMMUNOLOGY,
2007, 28 (01)
:5-11

Bechmann, Ingo
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany

Galea, Ian
论文数: 0 引用数: 0
h-index: 0
机构: Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany

Perry, V. Hugh
论文数: 0 引用数: 0
h-index: 0
机构: Goethe Univ Frankfurt, Inst Clin Neuroanat, D-60590 Frankfurt, Germany
[9]
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
[J].
Beers, David R.
;
Henkel, Jenny S.
;
Xiao, Qin
;
Zhao, Weihua
;
Wang, Jinghong
;
Yen, Albert A.
;
Siklos, Laszlo
;
McKercher, Scott R.
;
Appel, Stanley H.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2006, 103 (43)
:16021-16026

Beers, David R.
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Henkel, Jenny S.
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Xiao, Qin
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Zhao, Weihua
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Wang, Jinghong
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Yen, Albert A.
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Siklos, Laszlo
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

McKercher, Scott R.
论文数: 0 引用数: 0
h-index: 0
机构: Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA

Appel, Stanley H.
论文数: 0 引用数: 0
h-index: 0
机构:
Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA Methodist Neurol Inst, Dept Neurol, Houston, TX 77030 USA
[10]
5D4 keratan sulfate epitope identifies a subset of ramified microglia in normal central nervous system parenchyma
[J].
Bertolotto, A
;
Agresti, C
;
Castello, A
;
Manzardo, E
;
Riccio, A
.
JOURNAL OF NEUROIMMUNOLOGY,
1998, 85 (01)
:69-77

Bertolotto, A
论文数: 0 引用数: 0
h-index: 0
机构: Osped S Luigi, Div Univ Neurol, Ctr Sclerosi Multipla, I-10043 Orbassano, Italy

Agresti, C
论文数: 0 引用数: 0
h-index: 0
机构: Osped S Luigi, Div Univ Neurol, Ctr Sclerosi Multipla, I-10043 Orbassano, Italy

Castello, A
论文数: 0 引用数: 0
h-index: 0
机构: Osped S Luigi, Div Univ Neurol, Ctr Sclerosi Multipla, I-10043 Orbassano, Italy

Manzardo, E
论文数: 0 引用数: 0
h-index: 0
机构: Osped S Luigi, Div Univ Neurol, Ctr Sclerosi Multipla, I-10043 Orbassano, Italy

Riccio, A
论文数: 0 引用数: 0
h-index: 0
机构: Osped S Luigi, Div Univ Neurol, Ctr Sclerosi Multipla, I-10043 Orbassano, Italy