From bone marrow to microglia: barriers and avenues

被引:125
作者
Davoust, Nathalie [2 ]
Vuaillat, Carine [3 ]
Androdias, Geraldine [1 ]
Nataf, Serge [1 ]
机构
[1] Univ Lyon, Laennec Sch Med, INSERM, U842, F-69372 Lyon, France
[2] Univ Lyon, U851, INSERM, IFR Biosci, F-69007 Lyon, France
[3] Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA
关键词
D O I
10.1016/j.it.2008.01.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Microglia form a unique population of brain-resident macrophages. Although microglia have been involved in multiple disorders of the central nervous system (CNS), the issue of microglial renewal, under normal or pathological conditions, has been controversial. In mice, results from bone marrow chimera studies indicated that microglia are slowly but continuously replenished by bone marrow-derived cells. Moreover, such a microglial turnover was found to be greatly accelerated under multiple neurological conditions. However, recent works questioned the use of irradiation/reconstitution experiments to assess microglial turnover. Based on these different studies, we propose here a re-evaluation of microglia origin(s) in the inflamed CNS. We also discuss the therapeutic perspectives offered by the demonstration of an adult microglial lineage, from bone marrow to brain.
引用
收藏
页码:227 / 234
页数:8
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