Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes

被引：45

作者：

Dilda, Francesca ^{[1
]}

Gioia, Gloria ^{[1
]}

Pisani, Laura ^{[1
]}

Restelli, Laura ^{[1
]}

Lecchi, Cristina ^{[1
]}

Albonico, Francesca ^{[1
]}

Bronzo, Valerio ^{[1
]}

Mortarino, Michele ^{[1
]}

Ceciliani, Fabrizio ^{[1
,2
]}

机构：

[1] Univ Milan, Dipartimento Patol Anim Igiene & Sanita Pubbl Vet, I-20133 Milan, Italy

[2] Univ Milan, CISMA Ctr Interdipartimentale Studi Ghiandola Mam, I-20133 Milan, Italy

来源：

VETERINARY JOURNAL | 2012年 / 192卷 / 03期

关键词：

miRNA; Monocytes; Lipopolysaccharide; Staphylococcus aureus enterotoxin B; Bovine; INDUCTION;

D O I：

10.1016/j.tvjl.2011.08.018

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

MicroRNAs (miRNAs) are a family of regulatory molecules involved in many physiological processes, including activation of cells of the immune system. This study investigated the effect of Escherichia colt lipopolysaccharide (LPS) and Staphylococcus aureus enterotoxin B (SEB) on the expression of five miRNAs involved in the inflammatory response, including miR-9, miR-125b, miR-155, miR-146a and miR-223, in bovine CD14(+) cells (monocytes). Incubation of monocytes with SEB induced down-regulation of miR-155, miR-223 and miR-125b, but not the anti-inflammatory miRNA miR-146a. Conversely, incubation with LPS upregulated both miR-155 and miR-146a. In vitro incubation of isolated CD14(+) bovine monocytes with LPS and SEB elicited different and opposite expression of miRNAs reportedly involved in inflammatory reactions. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：514 / 516

页数：3

共 11 条

[1] Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows [J].

Bannerman, D. D. .

JOURNAL OF ANIMAL SCIENCE, 2009, 87 (13) :10-25

[2] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[3] Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals [J].

Bazzoni, Flavia ;

Rossato, Marzia ;

Fabbri, Marco ;

Gaudiosi, Daniele ;

Mirolo, Massimiliano ;

Mori, Laura ;

Tamassia, Nicola ;

Mantovani, Alberto ;

Cassatella, Marco A. ;

Locati, Massimo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5282-5287

[4] α1-Acid glycoprotein modulates apoptosis in bovine monocytes [J].

Ceciliani, Fabrizio ;

Pocacqua, Vanessa ;

Miranda-Ribera, Alba ;

Bronzo, Valerio ;

Lecchi, Cristina ;

Sartorelli, Paola .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2007, 116 (3-4) :145-152

[5] Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues [J].

Coutinho, Luiz L. ;

Matukumalli, Lakshmi K. ;

Sonstegard, Tad S. ;

Van Tassell, Curtis P. ;

Gasbarre, Louis C. ;

Capuco, Anthony V. ;

Smith, Timothy P. L. .

PHYSIOLOGICAL GENOMICS, 2007, 29 (01) :35-43

[6] Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs [J].

Hata, Taketoshi ;

Murakami, Kosuke ;

Nakatani, Hajime ;

Yamamoto, Yasunari ;

Matsuda, Tsukasa ;

Aoki, Naohito .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (02) :528-533

[7] Detection of microRNA Expression in Human Peripheral Blood Microvesicles [J].

Hunter, Melissa Piper ;

Ismail, Noura ;

Zhang, Xiaoli ;

Aguda, Baltazar D. ;

Lee, Eun Joo ;

Yu, Lianbo ;

Xiao, Tao ;

Schafer, Jeffrey ;

Lee, Mei-Ling Ting ;

Schmittgen, Thomas D. ;

Nana-Sinkam, S. Patrick ;

Jarjoura, David ;

Marsh, Clay B. .

PLOS ONE, 2008, 3 (11)

[8] microRNAs and the immune response [J].

Tsitsiou, Eleni ;

Lindsay, Mark A. .

CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (04) :514-520

[9] miR-146a Is Critical for Endotoxin-induced Tolerance IMPLICATION IN INNATE IMMUNITY [J].

Nahid, Md A. ;

Pauley, Kaleb M. ;

Satoh, Minoru ;

Chan, Edward K. L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (50) :34590-34599

[10] Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens [J].

Skinner, NA ;

MacIsaac, CM ;

Hamilton, JA ;

Visvanathan, K .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 141 (02) :270-278

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