Predictive factors for successful renal denervation: should we use them in clinical trials?

被引：4

作者：

Barber-Chamoux, Nicolas ^{[1
,2
,3
]}

Esler, Murray D. ^{[2
,3
]}

机构：

[1] Clermont Ferrand Univ Hosp, Dept Cardiol, F-63003 Clermont Ferrand, France

[2] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, 75 Commercial Rd, Melbourne, Vic 3004, Australia

[3] Alfred Hosp, Ctr Heart, Melbourne, Vic 3004, Australia

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2017年 / 47卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Clinical trials; hypertension; renal denervation; sympathetic nervous system; BLOOD-PRESSURE RESPONSE; SYMPATHETIC-NERVOUS-SYSTEM; OBSTRUCTIVE SLEEP-APNEA; CHRONIC KIDNEY-DISEASE; RESISTANT HYPERTENSION; SYMPLICITY HTN-3; ARTERY STENOSIS; ATRIAL-FIBRILLATION; CATHETER; STIMULATION;

D O I：

10.1111/eci.12792

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Renal denervation (RDN) is facing various challenges to its initial claimed value in hypertension treatment. Major concerns are the choice of the patients and the technical efficacy of the RDN. Different factors have been described as predicting the capacity of RDN to decrease blood pressure. These factors are related to the patients, the procedure and the tools to confirm successful neural ablation. Their use in future trials should help to improve RDN trials understanding and outcomes. This review summarizes the different predictive factors available and their potential benefits in patient selection and in procedure guidance.

引用

页码：860 / 867

页数：8

共 73 条

[1] Micro-anatomy of the renal sympathetic nervous system: A human postmortem histologic study [J].

Atherton, Daniel S. ;

Deep, Nicholas L. ;

Mendelsohn, Farrell O. .

CLINICAL ANATOMY, 2012, 25 (05) :628-633

[2] Adherence to Antihypertensive Treatment and the Blood Pressure-Lowering Effects of Renal Denervation in the Renal Denervation for Hypertension (DENERHTN) Trial [J].

Azizi, Michel ;

Pereira, Helena ;

Hamdidouche, Idir ;

Gosse, Philippe ;

Monge, Matthieu ;

Bobrie, Guillaume ;

Delsart, Pascal ;

Mounier-Vehier, Claire ;

Courand, Pierre-Yves ;

Lantelme, Pierre ;

Denolle, Thierry ;

Dourmap-Collas, Caroline ;

Girerd, Xavier ;

Halimi, Jean Michel ;

Zannad, Faiez ;

Ormezzano, Olivier ;

Vaisse, Bernard ;

Herpin, Daniel ;

Ribstein, Jean ;

Chamontin, Bernard ;

Mourad, Jean-Jacques ;

Ferrari, Emile ;

Plouin, Pierre-Francois ;

Jullien, Vincent ;

Sapoval, Marc ;

Chatellier, Gilles .

CIRCULATION, 2016, 134 (12) :847-857

[3] Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial [J].

Azizi, Michel ;

Sapoval, Marc ;

Gosse, Philippe ;

Monge, Matthieu ;

Bobrie, Guillaume ;

Delsart, Pascal ;

Midulla, Marco ;

Mounier-Vehier, Claire ;

Courand, Pierre-Yves ;

Lantelme, Pierre ;

Denolle, Thierry ;

Dourmap-Collas, Caroline ;

Trillaud, Herve ;

Pereira, Helena ;

Plouin, Pierre-Francois ;

Chatellier, Gilles .

LANCET, 2015, 385 (9981) :1957-1965

[4] EFFECT OF RENAL SYMPATHETIC-NERVE STIMULATION ON PROXIMAL WATER AND SODIUM-REABSORPTION [J].

BELLOREUSS, E ;

TREVINO, DL ;

GOTTSCHALK, CW .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (04) :1104-1107

[5] Randomised, blinded and controlled comparative study of chemical and radiofrequency-based renal denervation in a porcine model [J].

Bertog, Stefan ;

Fischell, Tim A. ;

Vega, Felix ;

Ghazarossian, Vartan ;

Pathak, Atul ;

Vaskelyte, Laura ;

Kent, Darrin ;

Sievert, Horst ;

Ladich, Elena ;

Yahagi, Kazuyuki ;

Virmani, Renu .

EUROINTERVENTION, 2017, 12 (15) :1898-1906

[6] A Controlled Trial of Renal Denervation for Resistant Hypertension [J].

Bhatt, Deepak L. ;

Kandzari, David E. ;

O'Neill, William W. ;

D'Agostino, Ralph ;

Flack, John M. ;

Katzen, Barry T. ;

Leon, Martin B. ;

Liu, Minglei ;

Mauri, Laura ;

Negoita, Manuela ;

Cohen, Sidney A. ;

Oparil, Suzanne ;

Rocha-Singh, Krishna ;

Townsend, Raymond R. ;

Bakris, George L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (15) :1393-1401

[7] Effects of Renal Sympathetic Denervation on Arterial Stiffness and Central Hemodynamics in Patients With Resistant Hypertension [J].

Brandt, Mathias C. ;

Reda, Sara ;

Mahfoud, Felix ;

Lenski, Matthias ;

Boehm, Michael ;

Hoppe, Uta C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (19) :1956-1965

[8] CHROMOGRANIN A AS A PREDICTIVE MARKER OF SUCCESSFUL RENAL DENERVATION [J].

Chamoux, N. Barber ;

Eikelis, N. ;

Pereira, B. ;

Hering, D. ;

Marusic, P. ;

Lambert, E. ;

Schlaich, M. ;

Lambert, G. ;

Esler, M. .

JOURNAL OF HYPERTENSION, 2017, 35 :E66-E66

[9] Preliminary Effects of Renal Denervation With Saline Irrigated Catheter on Cardiac Systolic Function in Patients With Heart Failure: A Prospective, Randomized, Controlled, Pilot Study [J].

Chen, Weijie ;

Ling, Zhiyu ;

Xu, Yanping ;

Liu, Zengzhang ;

Su, Li ;

Du, Huaan ;

Xiao, Peilin ;

Lan, Xianbin ;

Shan, Qijun ;

Yin, Yuehui .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2017, 89 (04) :E153-E161

[10] The effect of two different renal denervation strategies on blood pressure in resistant hypertension: Comparison of full-length versus proximal renal artery ablation [J].

Chen, Weijie ;

Ling, Zhiyu ;

Du, Huaan ;

Song, Wenxin ;

Xu, Yanping ;

Liu, Zengzhang ;

Su, Li ;

Xiao, Peilin ;

Yuan, Yuelong ;

Lu, Jiayi ;

Zhang, Jianhong ;

Li, Zhifeng ;

Shao, Jiang ;

Zhong, Bin ;

Zhou, Bei ;

Woo, Kamsang ;

Yin, Yuehui .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2016, 88 (05) :786-795

← 1 2 3 4 5 6 7 8 →