Detection by screening mammography is a powerful independent predictor of survival in women diagnosed with breast cancer

被引:43
作者
Gill, PG
Farshid, G
Luke, CG
Roder, DM
机构
[1] Royal Adelaide Hosp, Breast Endocrine & Surg Oncol Unit, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Dept Surg, Adelaide, SA 5000, Australia
[3] Inst Med & Vet Sci, Adelaide, SA 5000, Australia
[4] Dept Human Serv, Epidemiol Branch, Adelaide, SA, Australia
[5] Canc Council S Australia, Adelaide, SA, Australia
关键词
breast cancer; mammographic detection; prognosis;
D O I
10.1016/S0960-9776(03)00169-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Four hundred and sixteen invasive breast cancers, detected initially by mammography, were compared with 929 presenting symptomatically, all treated at a South Australian teaching hospital. Predictable differences included tower stages and grades, less vascular invasion and proliferative activity, and more hormone-receptor expression among the mammographically detected. Unpredicted differences included significantly higher survivals for mammographically detected cases throughout the 9 year follow-up period after adjusting for stage and the Nottingham Prognostic Index. In a multivariable analysis, differences in stage, grade, and hormone receptor expression accounted for only about half the survival advantage of mammographically detected tumours. Accounting for additional person and tumour characteristics had only a marginal effect on this result. This suggests that detection by mammography has independent favourabte prognostic significance beyond that explained by conventional indicators. If confirmed, this finding would have important implications for the prognostic advice given to women and may merit further investigation into its underlying biological mechanisms. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:15 / 22
页数:8
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