Prognostic Value of Cystatin C-Derived Estimated Glomerular Filtration Rate in Patients with Acute Heart Failure

被引：13

作者：

Jang, Se Yong ^{[1
,2
,3
]}

Yang, Dong Heon ^{[1
,2
,3
]}

Kim, Hyeon Jeong ^{[2
]}

Park, Bo Eun ^{[2
]}

Park, Yoon Jung ^{[2
]}

Kim, Hong Nyun ^{[2
]}

Kim, Nam Kyun ^{[3
]}

Bae, Myung Hwan ^{[1
,2
]}

Lee, Jang Hoon ^{[1
,2
]}

Park, Hun Sik ^{[1
,2
]}

Cho, Yongkeun ^{[1
,2
]}

Chae, Shung Chull ^{[1
,2
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[2] Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea

[3] Kyungpook Natl Univ, Cardiol Ctr, Chilgok Hosp, Daegu, South Korea

来源：

CARDIORENAL MEDICINE | 2020年 / 10卷 / 04期

关键词：

Glomerular filtration rate; Heart failure; Prognosis; Cystatin C; RENAL-FUNCTION; SERUM CREATININE; DISEASE; MARKER; DYSFUNCTION; EQUATION; EVENTS; IMPACT; KIDNEY; DIET;

D O I：

10.1159/000504084

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background:Renal function is closely related to cardiac function and an important prognostic marker in heart failure.Objective:We aimed to test the prognostic value of cystatin C (cysC)-derived estimated glomerular filtration rates (eGFR) in comparison with eGFRs from creatinine solely based equations in patients with acute heart failure (AHF).Methods:This study included 262 patients (65.8 +/- 14.9 years old, 126 male) with AHF. Prognostic value of the eGFRs, from cysC-based equations chronic kidney disease epidemiology collaboration (CKD-EPI-cysC and CKD-EPI-creatinine [cr]-cysC equations) were compared with eGFRs calculated from serum creatinine levels only (Modification of Diet in Renal Disease [MDRD]-4 and CKD-EPI-cr equations). Prognosis was evaluated with the composite of all-cause mortality and hospitalization for heart failure within 1 year.Results:During the follow-up period (mean follow-up period, 264.0 +/- 136.1 days), 67 (25.6%) events occurred. Estimated GFR using CKD-EPI-cysC was the best for predicting 1-year outcome using receiver operating characteristic curve analysis (area under curve 0.585, 0.607, 0.669, and 0.652 for eGFRs from MDRD-4, CKD-EPI-cr, CKD-EPI-cysC, and CKD-EPI-cr-cysC respectively). The Kaplan-Meier survival curve analysis showed that only the eGFRs classification from the equations based on cysC significantly predicted 1-year outcome in patients with AHF.Conclusions:Estimated GFRs calculated with cysC predicted the prognosis more accurately in patients with AHF than the eGFRs from creatinine only equations.

引用

页码：232 / 242

页数：11

共 29 条

[1] Plasma Volume and Renal Function Predict Six-Month Survival after Hospitalization for Acute Decompensated Heart Failure [J].