Ynones in Reflex-Michael Addition, CuAAC, and Cycloaddition, as Well as their Use as Nucleophilic Enols, Electrophilic Ketones, and Allenic Precursors

被引：24

作者：

Wang, Zhan-Yong ^{[1
]}

Wang, Kai-Kai ^{[1
]}

Chen, Rongxiang ^{[1
]}

Liu, Huan ^{[1
]}

Chen, Kaijun ^{[2
]}

机构：

[1] Xinxiang Univ, Coll Chem & Chem Engn, Xinxiang 453000, Henan, Peoples R China

[2] Lishui Univ, Dept Chem, 1 Xueyuan Rd, Lishui 323000, Zhejiang, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Tandem reactions; Michael addition; Enols; Terminal alkynes; Ynones; DIELS-ALDER REACTION; CARBON SIGMA-BONDS; TANDEM CYCLIZATION; ALKYNYL KETONES; INTRAMOLECULAR CYCLIZATION; STEREOSELECTIVE-SYNTHESIS; OXIDATIVE CYCLIZATION; DICTYODENDRINS B; FACILE SYNTHESIS; SULFINIC ACIDS;

D O I：

10.1002/ejoc.201901921

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The great success of ynones in synthesis is rooted in their multiple functional groups. Herein, reactions triggered by the reflex-Michael addition, ynones in copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC), and formal cycloaddition as well as the use of ynones as nucleophilic enols, electrophilic ketones, and allenic precursors were thoroughly discussed and summarized. Multi-component reactions, rearrangements, cycloadditions, regio- and stereoselective synthesis, coupling, and cycloaddition are depicted in detail. This review focused on advances of ynones chemistry in the last decade (2009-2019). We hope it will promote future research in this area.

引用

页码：2456 / 2474

页数：19

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