共 42 条
Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity
被引:63
作者:

Wan, Min
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Easton, Rachael M.
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h-index: 0
机构:
Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Gleason, Catherine E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Monks, Bobby R.
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h-index: 0
机构:
Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Ueki, Kohjiro
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h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Tokyo, Japan Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Kahn, C. Ronald
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h-index: 0
机构:
Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02115 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA

Birnbaum, Morris J.
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h-index: 0
机构:
Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
机构:
[1] Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
[2] Univ Tokyo, Grad Sch Med, Tokyo, Japan
[3] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02115 USA
关键词:
BROWN ADIPOSE-TISSUE;
SKELETAL-MUSCLE;
GLUCOSE-HOMEOSTASIS;
INSULIN-RESISTANCE;
UNCOUPLING PROTEIN-3;
KINASE-B;
METABOLIC SYNDROME;
HEPATIC STEATOSIS;
EXERCISE;
LACKING;
D O I:
10.1128/MCB.05806-11
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Akt is encoded by a gene family for which each isoform serves distinct but overlapping functions. Based on the phenotypes of the germ line gene disruptions, Akt1 has been associated with control of growth, whereas Akt2 has been linked to metabolic regulation. Here we show that Akt1 serves an unexpected role in the regulation of energy metabolism, as mice deficient for Akt1 exhibit protection from diet-induced obesity and its associated insulin resistance. Although skeletal muscle contributes most of the resting and exercising energy expenditure, muscle-specific deletion of Akt1 does not recapitulate the phenotype, indicating that the role of Akt1 in skeletal muscle is cell nonautonomous. These data indicate a previously unknown function of Akt1 in energy metabolism and provide a novel target for treatment of obesity.
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页码:96 / 106
页数:11
相关论文
共 42 条
[1]
S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase
[J].
Aguilar, Victor
;
Alliouachene, Samira
;
Sotiropoulos, Athanassia
;
Sobering, Andrew
;
Athea, Yoni
;
Djouadi, Fatima
;
Miraux, Sylvain
;
Thiaudiere, Eric
;
Foretz, Marc
;
Viollet, Benoit
;
Diolez, Philippe
;
Bastin, Jean
;
Benit, Paule
;
Rustin, Pierre
;
Carling, David
;
Sandri, Marco
;
Ventuar-Clapier, Renee
;
Pende, Mario
.
CELL METABOLISM,
2007, 5 (06)
:476-487

Aguilar, Victor
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Alliouachene, Samira
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Sotiropoulos, Athanassia
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Sobering, Andrew
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Athea, Yoni
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Djouadi, Fatima
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Miraux, Sylvain
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Thiaudiere, Eric
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Foretz, Marc
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Viollet, Benoit
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Diolez, Philippe
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Bastin, Jean
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Benit, Paule
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Rustin, Pierre
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Carling, David
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Sandri, Marco
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Ventuar-Clapier, Renee
论文数: 0 引用数: 0
h-index: 0
机构: INSERM, U845, F-75015 Paris, France

Pende, Mario
论文数: 0 引用数: 0
h-index: 0
机构:
INSERM, U845, F-75015 Paris, France INSERM, U845, F-75015 Paris, France
[2]
Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
[J].
Almind, Katrine
;
Manieri, Monia
;
Sivitz, William I.
;
Cinti, Saverio
;
Kahn, C. Ronald
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2007, 104 (07)
:2366-2371

Almind, Katrine
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Manieri, Monia
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Sivitz, William I.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Cinti, Saverio
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA

Kahn, C. Ronald
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA
[3]
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
[J].
Barnett, SF
;
Defeo-Jones, D
;
Fu, S
;
Hancock, PJ
;
Haskell, KM
;
Jones, RE
;
Kahana, JA
;
Kral, AM
;
Leander, K
;
Lee, LL
;
Malinowski, J
;
McAvoy, EM
;
Nahas, DD
;
Robinson, RG
;
Huber, HE
.
BIOCHEMICAL JOURNAL,
2005, 385
:399-408

Barnett, SF
论文数: 0 引用数: 0
h-index: 0
机构:
Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Defeo-Jones, D
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Fu, S
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Hancock, PJ
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Haskell, KM
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Jones, RE
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Kahana, JA
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Kral, AM
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Leander, K
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Lee, LL
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Malinowski, J
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

McAvoy, EM
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Nahas, DD
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Robinson, RG
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA

Huber, HE
论文数: 0 引用数: 0
h-index: 0
机构: Merck & Co Inc, Dept Canc Res, W Point, PA 19454 USA
[4]
A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes
[J].
Butler, Andrew A.
;
Kozak, Leslie P.
.
DIABETES,
2010, 59 (02)
:323-329

Butler, Andrew A.
论文数: 0 引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Metab & Aging, Jupiter, FL USA Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA

Kozak, Leslie P.
论文数: 0 引用数: 0
h-index: 0
机构:
Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA
[5]
Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass
[J].
Buzzi, Francesca
;
Xu, Linhua
;
Zuellig, Richard A.
;
Boller, Simone B.
;
Spinas, Giatgen A.
;
Hynx, Debby
;
Chang, Zai
;
Yang, Zhongzhou
;
Hemmings, Brian A.
;
Tschopp, Oliver
;
Niessen, Markus
.
MOLECULAR AND CELLULAR BIOLOGY,
2010, 30 (03)
:601-612

Buzzi, Francesca
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, CH-8091 Zurich, Switzerland
ETH, Swiss Fed Inst Technol, Competence Ctr Syst Physiol & Metab Dis, CH-8093 Zurich, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Xu, Linhua
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, CH-8091 Zurich, Switzerland
ETH, Swiss Fed Inst Technol, Competence Ctr Syst Physiol & Metab Dis, CH-8093 Zurich, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Zuellig, Richard A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, CH-8091 Zurich, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Boller, Simone B.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, CH-8091 Zurich, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Spinas, Giatgen A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, CH-8091 Zurich, Switzerland
ETH, Swiss Fed Inst Technol, Competence Ctr Syst Physiol & Metab Dis, CH-8093 Zurich, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Hynx, Debby
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Chang, Zai
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Model Anim Res Ctr, MOE Key Lab Model Anim Dis Study, Nanjing 210061, Peoples R China Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Yang, Zhongzhou
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Model Anim Res Ctr, MOE Key Lab Model Anim Dis Study, Nanjing 210061, Peoples R China Univ Zurich Hosp, CH-8091 Zurich, Switzerland

Hemmings, Brian A.
论文数: 0 引用数: 0
h-index: 0
机构:
Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland Univ Zurich Hosp, CH-8091 Zurich, Switzerland

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:
[6]
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
[J].
Chen, WS
;
Xu, PZ
;
Gottlob, K
;
Chen, ML
;
Sokol, K
;
Shiyanova, T
;
Roninson, I
;
Weng, W
;
Suzuki, R
;
Tobe, K
;
Kadowaki, T
;
Hay, N
.
GENES & DEVELOPMENT,
2001, 15 (17)
:2203-2208

Chen, WS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Xu, PZ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Gottlob, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Chen, ML
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Sokol, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Shiyanova, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Roninson, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Weng, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Suzuki, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Tobe, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Kadowaki, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA

Hay, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Illinois, Coll Med, Dept Mol Genet, Chicago, IL 60607 USA
[7]
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
[J].
Cho, H
;
Thorvaldsen, JL
;
Chu, QW
;
Feng, F
;
Birnbaum, MJ
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (42)
:38349-38352

Cho, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

Thorvaldsen, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

Chu, QW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

Feng, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

Birnbaum, MJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
[8]
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
[J].
Cho, H
;
Mu, J
;
Kim, JK
;
Thorvaldsen, JL
;
Chu, QW
;
Crenshaw, EB
;
Kaestner, KH
;
Bartolomei, MS
;
Shulman, GI
;
Birnbaum, MJ
.
SCIENCE,
2001, 292 (5522)
:1728-1731

Cho, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Mu, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Kim, JK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Thorvaldsen, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Chu, QW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Crenshaw, EB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Kaestner, KH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Bartolomei, MS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Shulman, GI
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

Birnbaum, MJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
[9]
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
[J].
Choi, Cheol Soo
;
Fillmore, Jonathan J.
;
Kim, Jason K.
;
Liu, Zhen-Xiang
;
Kim, Sheene
;
Collier, Emily F.
;
Kulkarni, Ameya
;
Distefano, Alberto
;
Hwang, Yu-Jin
;
Kahn, Mario
;
Chen, Yan
;
Yu, Chunli
;
Moore, Irene K.
;
Reznick, Richard M.
;
Higashimori, Takamasa
;
Shulman, Gerald I.
.
JOURNAL OF CLINICAL INVESTIGATION,
2007, 117 (07)
:1995-2003

Choi, Cheol Soo
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Fillmore, Jonathan J.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Kim, Jason K.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Liu, Zhen-Xiang
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Kim, Sheene
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Collier, Emily F.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Kulkarni, Ameya
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Distefano, Alberto
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Hwang, Yu-Jin
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Kahn, Mario
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Chen, Yan
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Yu, Chunli
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Moore, Irene K.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Reznick, Richard M.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Higashimori, Takamasa
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA

Shulman, Gerald I.
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06536 USA
[10]
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
[J].
Clapham, JC
;
Arch, JRS
;
Chapman, H
;
Haynes, A
;
Lister, C
;
Moore, GBT
;
Piercy, V
;
Carter, SA
;
Lehner, I
;
Smith, SA
;
Beeley, LJ
;
Godden, RJ
;
Herrity, N
;
Skehel, M
;
Changani, KK
;
Hockings, PD
;
Reid, DG
;
Squires, SM
;
Hatcher, J
;
Trail, B
;
Latcham, J
;
Rastan, S
;
Harper, AJ
;
Cadenas, S
;
Buckingham, JA
;
Brand, MD
;
Abuin, A
.
NATURE,
2000, 406 (6794)
:415-418

Clapham, JC
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Arch, JRS
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Chapman, H
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Haynes, A
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Lister, C
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Moore, GBT
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Piercy, V
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Carter, SA
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Lehner, I
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Smith, SA
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Beeley, LJ
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Godden, RJ
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Herrity, N
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Skehel, M
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Changani, KK
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Hockings, PD
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Reid, DG
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Squires, SM
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Hatcher, J
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Trail, B
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Latcham, J
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Rastan, S
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Harper, AJ
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Cadenas, S
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Buckingham, JA
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Brand, MD
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机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

Abuin, A
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h-index: 0
机构: Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England