Combination Therapies against COVID-19

被引：2

作者：

Luo, Qunfeng ^{[1
]}

Zheng, Yunxi ^{[2
]}

Zhang, Jin ^{[1
]}

机构：

[1] Nanchang Univ, Sch Basic Med Sci, Nanchang 330047, Jiangxi, Peoples R China

[2] Nanchang Univ, Queen Marry Coll, Nanchang 330047, Jiangxi, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2022年 / 27卷 / 09期

基金：

中国国家自然科学基金;

关键词：

combination therapy; anti-SARS-CoV-2; complication; antiviral; anti-inflammation; EAST RESPIRATORY SYNDROME; CORONAVIRUS DISEASE 2019; CELL-DEPLETED PATIENT; HOSPITALIZED-PATIENTS; CLINICAL CHARACTERISTICS; SARS-COV-2; REPLICATION; LOPINAVIR-RITONAVIR; SPIKE PROTEIN; OPEN-LABEL; REMDESIVIR;

D O I：

10.31083/j.fbl2709257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus disease 2019 (COVID-19), which was announced as a pandemic leading to devastating economic and medical burden worldwide. The virus attacks the organ system across the body by binding to its receptor (for example, angiotensin converting enzyme 2) on the surface of the host cell of various organs. The patients present with a variety of pathological symptoms ranging from fever, cough and cytokine storm to acute respiratory distress syndrome (ARDS). Many combination therapies have been developed to combat the disease, via blocking one or more processes of the viral life cycle and/or relieving host complications simultaneously. In this review, the progress of those combination therapies containing at least one small molecule is updated. We believe it'll provide significant inspiration for further development of treatment strategy against SARS-CoV-2, especially its mutant variants.

引用

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