Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit

被引：46

作者：

Gay, Laurie J. ^{[1
]}

Felding-Habermann, Brunhilde ^{[1
]}

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

CANCER CELL | 2011年 / 20卷 / 05期

关键词：

TGF-BETA; PROGRESSION; CANCER;

D O I：

10.1016/j.ccr.2011.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis of epithelial tumors critically depends on acquisition of a disseminating phenotype that allows tumor cells to colonize distant organs. In this issue of Cancer Cell, Labelle et al. demonstrate that an epithelial-mesenchymal-like transition can be induced by interaction between platelets and tumor cells.

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收藏

页码：553 / 554

页数：2

相关论文

共 10 条

[1] Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer [J].

Boucharaba, A ;

Serre, CM ;

Grès, S ;

Saulnier-Blache, JS ;

Bordet, JC ;

Guglielmi, J ;

Clézardin, P ;

Peyruchaud, O .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (12) :1714-1725

[2] Deadly allies: the fatal interplay between platelets and metastasizing cancer cells [J].

Erpenbeck, Luise ;

Schoen, Michael P. .

BLOOD, 2010, 115 (17) :3427-3436

[3] Contribution of platelets to tumour metastasis [J].

Gay, Laurie J. ;

Felding-Habermann, Brunhilde .

NATURE REVIEWS CANCER, 2011, 11 (02) :123-134

[4] The basics of epithelial-mesenchymal transition [J].

Kalluri, Raghu ;

Weinberg, Robert A. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1420-1428

[5] Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity [J].

Kopp, Hans-Georg ;

Placke, Theresa ;

Salih, Helmut Rainer .

CANCER RESEARCH, 2009, 69 (19) :7775-7783

[6] Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis [J].

Labelle, Myriam ;

Begum, Shahinoor ;

Hynes, Richard O. .

CANCER CELL, 2011, 20 (05) :576-590

[7] L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest [J].

Läubli, H ;

Stevenson, JL ;

Varki, A ;

Varki, NM ;

Borsig, L .

CANCER RESEARCH, 2006, 66 (03) :1536-1542

[8] TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4 [J].

Padua, David ;

Zhang, Xiang H. -F. ;

Wang, Qiongqing ;

Nadal, Cristina ;

Gerald, William L. ;

Gomis, Roger R. ;

Massague, Joan .

CELL, 2008, 133 (01) :66-77

[9] Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells [J].

Palumbo, JS ;

Talmage, KE ;

Massari, JV ;

La Jeunesse, CM ;

Flick, MJ ;

Kombrinck, KW ;

Jirousková, M ;

Degen, JL .

BLOOD, 2005, 105 (01) :178-185

[10] TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression [J].

Yang, Li ;

Pang, Yanli ;

Moses, Harold L. .

TRENDS IN IMMUNOLOGY, 2010, 31 (06) :220-227