A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics

被引：117

作者：

Hemnes, Anna R. ^{[1
]}

Beck, Gerald J. ^{[2
]}

Newman, John H. ^{[1
]}

Abidov, Aiden ^{[3
]}

Aldred, Micheala A. ^{[2
]}

Barnard, John ^{[2
]}

Rosenzweig, Erika Berman ^{[4
]}

Borlaug, Barry A. ^{[5
]}

Chung, Wendy K. ^{[4
]}

Comhair, Suzy A. A. ^{[2
]}

Erzurum, Serpil C. ^{[2
]}

Frantz, Robert P. ^{[5
]}

Gray, Michael P. ^{[6
]}

Grunig, Gabriele ^{[7
]}

Hassoun, Paul M. ^{[8
]}

Hill, Nicholas S. ^{[9
]}

Horn, Evelyn M. ^{[10
]}

Hu, Bo ^{[2
]}

Lempel, Jason K. ^{[2
]}

Maron, Bradley A. ^{[11
]}

Mathai, Stephen C. ^{[8
]}

Olman, Mitchell A. ^{[2
]}

Rischard, Franz P. ^{[12
]}

Systrom, David M. ^{[11
]}

Tang, H. Wilson ^{[2
]}

Waxman, Aaron B. ^{[11
]}

Xiao, Lei ^{[13
]}

Yuan, Jason X. -J. ^{[12
]}

Leopold, Jane A. ^{[11
]}

机构：

[1] Vanderbilt Univ, T1218 Med Ctr N,1161 21st Ave S, Nashville, TN 37235 USA

[2] Cleveland Clin, Cleveland, OH 44106 USA

[3] Wayne State Univ, John D Dingell VAMC, Detroit, MI USA

[4] Columbia Univ, New York, NY USA

[5] Mayo Clin, Rochester, MN USA

[6] Pulm Hypertens Assoc, Silver Spring, MD USA

[7] NYU, Med Ctr, New York, NY 10003 USA

[8] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

[9] Tufts Med Ctr, Boston, MA USA

[10] Weill Cornell Med, New York, NY USA

[11] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[12] Univ Arizona, Tucson, AZ USA

[13] NHLBI, Bldg 10, Bethesda, MD 20892 USA

来源：

CIRCULATION RESEARCH | 2017年 / 121卷 / 10期

关键词：

diagnosis; hypertension; pulmonary; National Heart; Lung; and Blood Institute (US); National Institutes of Health (US); pulmonary artery; HEART-ASSOCIATION ELECTROCARDIOGRAPHY; OF-CARDIOLOGY-FOUNDATION; OBSTRUCTIVE SLEEP-APNEA; AMERICAN-COLLEGE; ECHOCARDIOGRAPHIC-ASSESSMENT; ARRHYTHMIAS COMMITTEE; SCIENTIFIC STATEMENT; CLINICAL CARDIOLOGY; SYSTEMIC-SCLEROSIS; HYPERTENSION;

D O I：

10.1161/CIRCRESAHA.117.311737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The National Institutes of Health (NIH)/National Heart, Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the current pulmonary hypertension (PH) classification based on shared biological features. PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping, and blood will be acquired for comprehensive omic analyses that will focus on discovery of molecular-based subtypes of pulmonary vascular disease (PVD) through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.

引用

页码：1136 / +

页数：44

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