New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

被引：11
作者：
Ankudey, Frank Joy [2 ]
Kiprof, Paul [2 ]
Stromquist, Emily R. [2 ]
Chang, Leng Chee [1 ,2 ]
机构：
[1] Univ Hawaii, Coll Pharm, Dept Pharmaceut Sci, Hilo, HI 96720 USA
[2] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA
来源：
PLANTA MEDICA | 2008年 / 74卷 / 05期
关键词：
bromotyrosine alkaloids; protein phosphorylation inhibitors; marine sponge; Aplysinella sp; hyphae formation inhibition;
D O I：
10.1055/s-2008-1074506
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new bromotyrosine-derived alkaloid, (+)-aply-sinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.
引用
收藏
页码：555 / 559
页数：5
相关论文
共 19 条
  • [1] 2 EPIMERIC DIBROMO NITRILES FROM THE AUSTRALIAN SPONGE APLYSINA-LAEVIS
    CAPON, RJ
    MACLEOD, JK
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1987, 40 (02) : 341 - 346
  • [2] CHEMISTRY OF VERONGIDA SPONGES .2. CONSTITUENTS OF THE CARIBBEAN SPONGE APLYSINA-FISTULARIS FORMA FULVA
    CIMINIELLO, P
    COSTANTINO, V
    FATTORUSSO, E
    MAGNO, S
    MANGONI, A
    PANSINI, M
    [J]. JOURNAL OF NATURAL PRODUCTS, 1994, 57 (06): : 705 - 712
  • [3] Chemistry of Verongida sponges .7. Bromocompounds from the Caribbean sponge Aplysina archeri.
    Ciminiello, P
    DellAversano, C
    Fattorusso, E
    Magno, S
    Carrano, L
    Pansini, M
    [J]. TETRAHEDRON, 1996, 52 (29) : 9863 - 9868
  • [4] DAMBROISO M, 1982, TETRAHEDRON LETT, V23, P4430
  • [5] Bromotyrosine-derived metabolites from the sponge Aiolochroia crassa
    Gao, HF
    Kelly, M
    Hamann, MT
    [J]. TETRAHEDRON, 1999, 55 (32) : 9717 - 9726
  • [6] DETERMINATION OF CELL NUMBER IN MONOLAYER-CULTURES
    GILLIES, RJ
    DIDIER, N
    DENTON, M
    [J]. ANALYTICAL BIOCHEMISTRY, 1986, 159 (01) : 109 - 113
  • [7] EFFECTS OF PROTEIN-KINASE INHIBITORS ON INVITRO PROTEIN-PHOSPHORYLATION AND CELLULAR-DIFFERENTIATION OF STREPTOMYCES-GRISEUS
    HONG, SK
    MATSUMOTO, A
    HORINOUCHI, S
    BEPPU, T
    [J]. MOLECULAR AND GENERAL GENETICS, 1993, 236 (2-3): : 347 - 354
  • [8] 3 BROMOTYROSINE DERIVATIVES, ONE TERMINATING IN AN UNPRECEDENTED DIKETOCYCLOPENTENYLIDENE ENAMINE
    ICHIBA, T
    SCHEUER, PJ
    KELLYBORGES, M
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (15) : 4149 - 4150
  • [9] Kijjoa A, 2002, Z NATURFORSCH C, V57, P732
  • [10] KONIG GM, 1993, HETEROCYCLES, V36, P1351
12