Application of Chitosan/PVA Nano fiber as a potential wound dressing for streptozotocin-induced diabetic rats

被引：88
作者：
Majd, Saeed Ahmadi [1 ]
Khorasgani, Mohammad Rabbani [1 ]
Moshtaghian, Seyed Jamal [1 ]
Talebi, Ardeshir [2 ]
Khezri, Maryam [1 ]
机构：
[1] Univ Isfahan, Esfahan, Iran
[2] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 92卷
关键词：
Chitosan/PVA Nano fiber; Wound dressing; Rat; Diabetes; Streptozotocin;
D O I：
10.1016/j.ijbiomac.2016.06.035
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes mellitus is a worldwide health problem affecting 1-2% of the population of world with noticeable morbidity and mortality. Vascular events such as hypertension, nephropathy, neuropathy and retinopathy are happened in diabetic patients. Decline in tissue blood circulation may causes hypoxia and finally may leads to slow wound healing and amputation. PVA/Chitosan Nano fiber wound dressings have high moisture vapor transmission rate and good antimicrobial activity(1) PCNWD substrate does not have any recognized cytotoxicity effects and has excellent odor absorbing capability. In the present study, Streptozotocin (STZ) is used to induce diabetes in rats, Skin ulcers are produced experimentally in the experimentally induced diabetic and non-diabetic rats. Then PCNWD used as wound dressing for 2 weeks period to evaluate its macroscopic and microscopic effects on wound healing in comparison with untreated diabetic and non-diabetic rats experimental ulcers. The findings of current study indicate significant acceleration in diabetes wound healing on the rats treated by PVA/Chitosan Nano fiber. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：1162 / 1168
页数：7
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