Janus kinase inhibitors in dermatology: Part I. A comprehensive review

被引：35

作者：

Chapman, Stephanie ^{[1
]}

Kwa, Michael ^{[1
]}

Gold, Linda Stein ^{[1
]}

Lim, Henry W. ^{[1
]}

机构：

[1] Henry Ford Hlth Syst, Dept Dermatol, 3031 W Grand Blvd,Suite 800, Detroit, MI 48202 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2022年 / 86卷 / 02期

关键词：

dermatology; immunodermatology; immunology; JAK inhibitor; JAK-STAT pathway; Janus kinase inhibitor; Janus kinase-signal transducer and activator of transcription pathway; review; EOSINOPHILIA; TOFACITINIB; DERMATITIS; PSORIASIS; EFFICACY; PHASE-3; SKIN;

D O I：

10.1016/j.jaad.2021.07.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is utilized by many proinflammatory molecules to mediate downstream effects and activate gene transcription. Activation of the JAK-STAT pathway contributes to a number of inflammatory dermatoses. Clinical trials and smaller studies have demonstrated the efficacy of JAK inhibitors in the treatment of a variety of dermatologic conditions. Here, we review the use of JAK inhibitors for the treatment of a wide range of dermatologic diseases in a two-part review series. ( J Am Acad Dermatol 2022;86:406-13.)

引用

页码：406 / 413

页数：8

共 50 条

[41] Janus Kinase Inhibitors and Non-Melanoma Skin Cancer
Greif, Charlotte S.
Srivastava, Divya
Nijhawan, Rajiv I.
CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2021, 22 (02)
[42] JAK inhibitors in dermatology: the road travelled and path ahead, a narrative review
Muddebihal, Aishwarya
Khurana, Ananta
Sardana, Kabir
EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2023, 16 (04) : 279 - 295
[43] Use of Janus kinase inhibitors for granulomatous dermatoses: A systematic review
Sood, Siddhartha
Heung, Martin
Georgakopoulos, Jorge R.
Mufti, Asfandyar
Prajapati, Vimal H.
Yeung, Jensen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2023, 89 (02) : 357 - 359
[44] Role of Janus Kinase Inhibitors in Therapy of Psoriasis
Sluczanowska-Glabowska, Sylwia
Ziegler-Krawczyk, Anna
Szumilas, Kamila
Pawlik, Andrzej
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (19)
[45] Janus kinase inhibitors in autoimmune bullous diseases
Huang, Dawei
Zhang, Yuexin
Kong, Luyang
Lu, Jiajing
Shi, Yuling
FRONTIERS IN IMMUNOLOGY, 2023, 14
[46] Efficacy of Janus kinase inhibitors in rheumatoid arthritis
Langbour, Camille
Rene, Jessica
Goupille, Philippe
Alegria, Guillermo Carvajal
INFLAMMATION RESEARCH, 2023, 72 (05) : 1121 - 1132
[47] Janus kinase inhibitors for the treatment of psoriatic arthritis
Raychaudhuri, Sanchita
Shah, Ruchi Jayeshbhai
Raychaudhuri, Smriti K.
Raychaudhuri, Siba P.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2024, 90 (02) : 186 - 191
[48] Efficacy of Janus kinase inhibitors in rheumatoid arthritis
Camille Langbour
Jessica Rene
Philippe Goupille
Guillermo Carvajal Alegria
Inflammation Research, 2023, 72 : 1121 - 1132
[49] The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases
Damsky, William
Peterson, Danielle
Ramseier, Julie
Al-Bawardy, Badr
Chun, Hyung
Proctor, Deborah
Strand, Vibeke
Flavell, Richard A.
King, Brett
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (03) : 814 - 826
[50] Systematic Review on the Efficacy and Safety of Oral Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis
Le, Michelle
Berman-Rosa, Melissa
Ghazawi, Feras M.
Bourcier, Marc
Fiorillo, Loretta
Gooderham, Melinda
Guenther, Lyn
Hanna, Sameh
Hong, H. Chih-Ho
Landells, Ian
Lansang, Perla
Marcoux, Danielle
Wiseman, Marni C.
Yeung, Jensen
Lynde, Charles
Litvinov, Ivan V.
FRONTIERS IN MEDICINE, 2021, 8

← 1 2 3 4 5 →