Janus kinase inhibitors in dermatology: Part I. A comprehensive review

被引：35

作者：

Chapman, Stephanie ^{[1
]}

Kwa, Michael ^{[1
]}

Gold, Linda Stein ^{[1
]}

Lim, Henry W. ^{[1
]}

机构：

[1] Henry Ford Hlth Syst, Dept Dermatol, 3031 W Grand Blvd,Suite 800, Detroit, MI 48202 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2022年 / 86卷 / 02期

关键词：

dermatology; immunodermatology; immunology; JAK inhibitor; JAK-STAT pathway; Janus kinase inhibitor; Janus kinase-signal transducer and activator of transcription pathway; review; EOSINOPHILIA; TOFACITINIB; DERMATITIS; PSORIASIS; EFFICACY; PHASE-3; SKIN;

D O I：

10.1016/j.jaad.2021.07.002

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is utilized by many proinflammatory molecules to mediate downstream effects and activate gene transcription. Activation of the JAK-STAT pathway contributes to a number of inflammatory dermatoses. Clinical trials and smaller studies have demonstrated the efficacy of JAK inhibitors in the treatment of a variety of dermatologic conditions. Here, we review the use of JAK inhibitors for the treatment of a wide range of dermatologic diseases in a two-part review series. ( J Am Acad Dermatol 2022;86:406-13.)

引用

页码：406 / 413

页数：8

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