Supramolecular organization of collagen and anti-cancer drugs

被引：0

作者：

Tomoaia, G. H. ^{[1
]}

Tomoaia-Cotisel, M. ^{[2
]}

Mocanu, A. ^{[2
]}

Horovitz, O. ^{[2
]}

Bobos, L. D. ^{[2
]}

Crisan, M. ^{[1
]}

Petean, I. ^{[2
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharmacy, Orthopaedy Traumatol & Dermatol Dept, Cluj Napoca 400132, Romania

[2] Univ Babes Bolyai, Fac Chem & Chem Engn, Dept Phys Chem, Cluj Napoca 400028, Romania

来源：

JOURNAL OF OPTOELECTRONICS AND ADVANCED MATERIALS | 2008年 / 10卷 / 04期

关键词：

collagen; fluorouracil; doxonibicin; self-assembly; AFM;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We have studied several biosystems comprising a fibrous protein, namely type 1 collagen (COL), which co-assembles with an anti-cancer drug, such as 5-fluorouracil (FLU) or doxorubicin (DOX), to form ordered films on glass or mica substrate, as visualized by atomic force microscopy. The anti-cancer drugs appear to lead to supramolecular collagen structures, with a remarkable nanoscale order, that mimics natural protein assemblies. Direct incorporation of such small molecules into the collagen assemblies represents a step toward rational design of nanostructured materials for a wide range of applications in synthetic biology and medicine, including the design of new drug delivery systems.

引用

页码：961 / 964

页数：4

共 18 条

[1] Effect of titanium carbide coating on the osseointegration response in vitro and in vivo [J].

Brama, Marina ;

Rhodes, Nicholas ;

Hunt, John ;

Ricci, Andrea ;

Teghil, Roberto ;

Migliaccio, Silvia ;

Della Rocca, Carlo ;

Leccisotti, Silvia ;

Lioi, Attilio ;

Scandurra, Marta ;

De Maria, Giovanni ;

Ferro, Daniela ;

Pu, Fanrong ;

Panzini, Gianluca ;

Politi, Laura ;

Scandurra, Roberto .

BIOMATERIALS, 2007, 28 (04) :595-608

[2]

Bratu I, 2007, J OPTOELECTRON ADV M, V9, P672

[3] Collagen films adsorbed on native and oxidized poly(ethylene terephtalate): morphology after drying [J].

De Cupere, VM ;

Rouxhet, PG .

SURFACE SCIENCE, 2001, 491 (03) :395-404

[4] Protein adsorption on model surfaces with controlled nanotopography and chemistry [J].

Denis, FA ;

Hanarp, P ;

Sutherland, DS ;

Gold, J ;

Mustin, C ;

Rouxhet, PG ;

Dufrêne, YF .

LANGMUIR, 2002, 18 (03) :819-828

[5] Influence of substratum surface properties on the organization of adsorbed collagen films:: In situ characterization by atomic force microscopy [J].

Dufrêne, YF ;

Marchal, TG ;

Rouxhet, PG .

LANGMUIR, 1999, 15 (08) :2871-2878

[6] Influence of the aggregation state in solution on the supramolecular organization of adsorbed type I collagen layers [J].

Dupont-Gillain, CC ;

Jacquemart, I ;

Rouxhet, PG .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, 43 (3-4) :179-186

[7] The effect of surface chemistry on the formation of thin films of native fibrillar collagen [J].

Elliott, John T. ;

Woodward, John T. ;

Umarji, Anita ;

Mei, Ying ;

Tona, Alessandro .

BIOMATERIALS, 2007, 28 (04) :576-585

[8] Factors and mechanisms determining the formation of fibrillar collagen structures in adsorbed phases [J].

Gurdak, Elzbieta ;

Rouxhet, Paul G. ;

Dupont-Gillain, Christine C. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2006, 52 (01) :76-88

[9] Protein binding to gold colloids [J].

Horovitz, Ossi ;

Tomoaia, Gheorghe ;

Mocanu, Aurora ;

Yupsanis, Traianos ;

Tomoaia-Cotisel, Maria .

GOLD BULLETIN, 2007, 40 (03) :213-218

[10] Nanostructured collagen layers obtained by adsorption and drying [J].

Jacquemart, I ;

Pamula, E ;

De Cupere, VM ;

Rouxhet, P ;

Dupont-Gillain, CC .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2004, 278 (01) :63-70

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