Microsatellite and chromosome instability in squamous cell laryngeal carcinoma

被引：1
作者：
Sasiadek, M
Stembalska-Kozlowska, A
Smigiel, R
Krecicki, T
Blin, N
Mirghomizadeh, F
机构：
[1] Med Univ Wroclaw, Dept Genet, PL-50368 Wroclaw, Poland
[2] Med Univ Wroclaw, Dept Pathophysiol, PL-50368 Wroclaw, Poland
[3] Med Univ Wroclaw, Dept Otolaryngol, PL-50368 Wroclaw, Poland
[4] Inst Anthropol & Human Genet, Tubingen, Germany
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2001年 / 19卷 / 02期
关键词：
head-and-neck squamous cell carcinoma; loss of heterozygosity; microsatellite instability; bleomycin test;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Head-and neck squamous cell carcinoma (HNSCC) represents almost 5% of all malignancies in Europe. The aetiology of HNSCC is complex, with both genetic and mutagenic factors involved. The aim of the present study was to investigate the loss of heterozygosity (LOH), mainly at tumour suppressor loci (using markers D1S2883, D2S123, D3S1611, D5S346, D7S501, D8S254, TP53, NM23), microsatellite instability (BAT25, 26, 40) and 'hidden chromosome instability' (bleomycin test) in patients with squamous cell larynx cancer. In a group of 20 patients LOH was observed mainly at the loci 3p (64.7%), 8q (71.4%), 17q (M1-30.8%, M2-25%, M3-38.5%). Despite chromosomal instability detected by bleomycin no microsatellite instability was observed.
引用
收藏
页码：401 / 405
页数：5
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