Ketamine enantiomers in the rapid and sustained antidepressant effects

被引：80

作者：

Muller, John ^{[1
]}

Pentyala, Sahana ^{[1
]}

Dilger, James ^{[1
]}

Pentyala, Srinivas ^{[1
]}

机构：

[1] Stony Brook Med Ctr, Dept Anesthesiol, Stony Brook, NY 11794 USA

来源：

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY | 2016年 / 6卷 / 03期

关键词：

depression; electroconvulsive therapy; ketamine; D-ASPARTATE ANTAGONIST; ELECTROCONVULSIVE-THERAPY; ANESTHESIA; ISOMERS; PHARMACOLOGY; MECHANISMS; DEPRESSION; PLASMA; TRIAL;

D O I：

10.1177/2045125316631267

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent evidence has suggested that the N-methyl-D-aspartate receptor antagonist ketamine shows significant therapeutic effects in major depression and bipolar disorder. This effect is especially important in treatment-resistant depression and depression with suicidal ideation. In this review we explain the mechanism of action, drug efficacy, and the side effects of ketamine; the antidepressive effects of ketamine; the individual effects of ketamine isomers, R(-) ketamine and S(+) ketamine; the effects of the combination of ketamine with electroconvulsive therapy; and the possible use of ketamine in treating depression.

引用

页码：185 / 192

页数：8

共 42 条

[1] S-(+)-ketamine. Cardiovascular interactions during total intravenous anaesthesia and analgosedation [J].

Adams, HA .

ANAESTHESIST, 1997, 46 (12) :1081-1087

[2] Intranasal Drug Delivery in Neuropsychiatry: Focus on Intranasal Ketamine for Refractory Depression [J].

Andrade, Chittaranjan .

JOURNAL OF CLINICAL PSYCHIATRY, 2015, 76 (05) :E628-E631

[3] NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses [J].

Autry, Anita E. ;

Adachi, Megunai ;

Nosyreva, Elena ;

Na, Elisa S. ;

Los, Maarten F. ;

Cheng, Peng-fei ;

Kavalali, Ege T. ;

Monteggia, Lisa M. .

NATURE, 2011, 475 (7354) :91-U109

[4] Antidepressant effects of ketamine in depressed patients [J].

Berman, RM ;

Cappiello, A ;

Anand, A ;

Oren, DA ;

Heninger, GR ;

Charney, DS ;

Krystal, JH .

BIOLOGICAL PSYCHIATRY, 2000, 47 (04) :351-354

[5] ISOMERISM AND ANESTHETIC DRUGS [J].

CALVEY, TN .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1995, 39 :83-90

[6] BIOAVAILABILITY, PHARMACOKINETICS, AND ANALGESIC ACTIVITY OF KETAMINE IN HUMANS [J].

CLEMENTS, JA ;

NIMMO, WS ;

GRANT, IS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (05) :539-542

[7] A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression [J].

Diazgranados, Nancy ;

Ibrahim, Lobna ;

Brutsche, Nancy E. ;

Newberg, Andrew ;

Kronstein, Phillip ;

Khalife, Sami ;

Kammerer, William A. ;

Quezado, Zenaide ;

Luckenbaugh, David A. ;

Salvadore, Giacomo ;

Machado-Vieira, Rodrigo ;

Manji, Husseini K. ;

Zarate, Carlos A., Jr. .

ARCHIVES OF GENERAL PSYCHIATRY, 2010, 67 (08) :793-802

[8] Taming the Ketamine Tiger [J].

Domino, Edward F. .

ANESTHESIOLOGY, 2010, 113 (03) :678-684

[9] Tissue uptake of ketamine and norketamine enantiomers in the rat - Indirect evidence for extrahepatic metabolic inversion [J].

Edwards, SR ;

Mather, LE .

LIFE SCIENCES, 2001, 69 (17) :2051-2066

[10] Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder [J].

Ghasemi, Mehdi ;

Kazemi, Mohammad H. ;

Yoosefi, Abolghasem ;

Ghasemi, Abbas ;

Paragomi, Pedram ;

Amini, Homayoun ;

Afzali, Mohammad H. .

PSYCHIATRY RESEARCH, 2014, 215 (02) :355-361

← 1 2 3 4 5 →