Absolute stereostructures of novel cytotoxic metabolites, gymnastatins A-E, from a Gymnascella species separated from a Halichonbdria sponge

被引：44

作者：

Amagata, T ^{[1
]}

Doi, M ^{[1
]}

Ohta, T ^{[1
]}

Minoura, K ^{[1
]}

Numata, A ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 21期

关键词：

D O I：

10.1039/a804466j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gymnastatins A-E have been isolated from a strain of Gymnascella dankaliensis originally separated from the sponge Halichondria japonica, and their absolute stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformations. Among them gymnastatins A-C exhibited significant cytotoxicity against cultured P388 cells.

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页码：3585 / 3599

页数：15

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