New ether diglycosides from Matayba guianensis with antiplasmodial activity

被引：28

作者：

de Mesquita, ML

Grellier, P

Blond, A

Brouard, JP

de Paula, JE

Espindola, LS ^{[1
]}

Mambu, L

机构：

[1] Univ Brasilia, Lab Farmacognosia, Fac Ciencias Saude, BR-70910900 Brasilia, DF, Brazil

[2] Museum Natl Hist Nat, Dept Regulat Dev Divers Mol, USM 0501, F-75231 Paris, France

[3] Univ Brasilia, Inst Biol, Dept Bot, Lab Anat Vegetal, BR-70910900 Brasilia, DF, Brazil

[4] Museum Natl Hist Nat, CNRS, UMR5154, USM 0502,Dept Regulat Dev Divers Mol, F-75231 Paris, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 14期

关键词：

antiplasmodial activity; ether diglycosides; matayosides A-D; Matayba guianensis; Sapindaceae;

D O I：

10.1016/j.bmc.2005.04.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new ether diglycosides (1-4), named matayosides A-D, were isolated from the root bark of Matayba guianensis, a plant exhibiting in vitro antiplasmodial activity. They were identified as hexadecyl-[O-2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl-(1 -> 2)]-6-0palmitoyl-beta-D-glucopyranoside, hexadecyl-[O-2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl-(1 -> 2)1-4,6-di-O-acetyl-beta-D-glucopyranoside, hexadecyl-[O-2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl-(1 -> 2)]-3,6-di-O-acetyl-beta-D-glucopyranoside and hexadecyl-[O-2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl-(1 -> 2)]-6-O-acetyl-beta-D-glucopyranoside, respectively. Their structures were established using one- and two-dimensional NMR techniques, mass spectrometry (MS) and MS/MS experiments. The compounds were found to inhibit the growth of Plasmodium falciparum in vitro with IC50 values ranging from 2.5 to 8.9 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4499 / 4506

页数：8

共 16 条

[1] FATTY-ACIDS VARIATION IN SAPINDACEAE [J].