X-ray crystal structure of the B component of Hemolysin BL from Bacillus cereus

被引：60

作者：

Madegowda, Mahendra ^{[1
]}

Eswaramoorthy, Subramaniam ^{[1
]}

Burley, Stephen K. ^{[2
]}

Swaminathan, Subramanyam ^{[1
]}

机构：

[1] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA

[2] SGX Pharmaceut Inc, San Diego, CA 92121 USA

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2008年 / 71卷 / 02期

关键词：

HBL-B; hemolysin; pore-formation; beta-hairpain;

D O I：

10.1002/prot.21888

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacillus cereus Hemolysin BL enterotoxin, a ternary complex of three proteins, is the causative agent of food poisoning and requires all three components for virulence. The X-ray structure of the binding domain of HBL suggests that it may form a Pore similar to other soluble channel forming proteins. A putative pathway of pore formation is discussed.

引用

页码：534 / 540

页数：7

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