Selective Formation of 1,5-Substituted Sulfonyl Triazoles Using Acetylides and Sulfonyl Azides

被引：67

作者：

Meza-Avina, Maria Elena ^{[1
]}

Patel, Mudita Kishor ^{[1
]}

Lee, Cylivia B. ^{[1
]}

Dietz, Thomas J. ^{[1
]}

Croatt, Mitchell P. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 12期

关键词：

CYCLOADDITION; WATER;

D O I：

10.1021/ol200696q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of acetylides with sulfonyl azides was found to selectively form 1,5-substituted sulfonyl triazoles. This reaction thus provides access to the regioisomeric product as compared to the popular copper-catalyzed azide-alkyne cycloaddition. The reaction is efficient and selective with a variety of alkyne sources and sulfonyl azides and can incorporate an additional electrophile to yield 1,4,5-trisubstituted sulfonyl triazoles.

引用

页码：2984 / 2987

页数：4

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